Back to search

Peptide record

TPDB25044

Antibacterial Anticancer Toxicity standard
47 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB25044
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
standard
No
A 47-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
RQCKRESNTFTGICIAKPPCRQACIREKFTDGHCSKVLRRCLCTKRC
Physicochemical Analysis
C225H384N78O63S8
MWY
C
5446.49
9.75
13
3
10
+9
13.67
-0.619
51.91
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
500
9.18
17
Residue Composition
number
2
A
7
R
1
N
1
D
8
C
2
E
2
Q
2
G
1
H
3
I
2
L
5
K
0
M
2
F
2
P
2
S
4
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 7 N: 1 D: 1 C: 8 E: 2 Q: 2 G: 2 H: 1 I: 3 L: 2 K: 5 M: 0 F: 2 P: 2 S: 2 T: 4 W: 0 Y: 0 V: 1
Chemical Descriptors
47
C225H384N78O63S8
5446.49
9.75
+9
13.67
-0.619
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
Toxicity
25.15±0.14 µM
Cytotoxic
IC50 | 25.15±0.14 | µM | target cell: Human umbilical vein endothelial cells HUVEC

Target

Human umbilical vein endothelial cells HUVEC

Source & Reference

NA
DBAASP
Structural and functional characterization of the membrane-permeabilizing activity of Nicotiana occidentalis defensin NoD173 and protein engineering to enhance oncolysis. | FASEB J | 2019
Evidence 2 Activity

Activity

IC50
Toxicity
25.15
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: HUVEC: IC50=25.15±0.14 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
FASEB J. 2019 May 33(5):6470-6482