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Peptide record

TPDB25042

Antibacterial Anticancer Toxicity standard
47 amino acids
Basic Information
3D PDB MODEL
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TPDB25042
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
standard
No
A 47-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
RQCKAESNTFTGICIAKPPCRKACIREKFTDGHCSKVLRRCLCTKRC
Physicochemical Analysis
C223H381N75O62S8
MWY
C
5361.42
9.70
13
3
11
+9
13.10
-0.494
54.04
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
500
9.33
16
Residue Composition
number
3
A
6
R
1
N
1
D
8
C
2
E
1
Q
2
G
1
H
3
I
2
L
6
K
0
M
2
F
2
P
2
S
4
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 3 R: 6 N: 1 D: 1 C: 8 E: 2 Q: 1 G: 2 H: 1 I: 3 L: 2 K: 6 M: 0 F: 2 P: 2 S: 2 T: 4 W: 0 Y: 0 V: 1
Chemical Descriptors
47
C223H381N75O62S8
5361.42
9.70
+9
13.10
-0.494
Evidence Records 4 records
Evidence 1 Activity

Activity

12% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
12% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structural and functional characterization of the membrane-permeabilizing activity of Nicotiana occidentalis defensin NoD173 and protein engineering to enhance oncolysis. | FASEB J | 2019
Evidence 2 Activity

Activity

IC50
Toxicity
6.20±0.07 µM
Cytotoxic
IC50 | 6.20±0.07 | µM | target cell: Human umbilical vein endothelial cells HUVEC

Target

Human umbilical vein endothelial cells HUVEC

Source & Reference

NA
DBAASP
Structural and functional characterization of the membrane-permeabilizing activity of Nicotiana occidentalis defensin NoD173 and protein engineering to enhance oncolysis. | FASEB J | 2019
Evidence 3 Activity

Activity

IC50
Toxicity
6.49±0.13 µM
Cytotoxic
IC50 | 6.49±0.13 | µM | target cell: Human dermal fibroblasts

Target

Human dermal fibroblasts

Source & Reference

NA
DBAASP
Structural and functional characterization of the membrane-permeabilizing activity of Nicotiana occidentalis defensin NoD173 and protein engineering to enhance oncolysis. | FASEB J | 2019
Evidence 4 Activity

Activity

IC50
Toxicity
6.20
Hemolytic Cytotoxic
Hemolytic_activity: Human red blood cells: with ∼12% lysis at the very high concentration (100 µM) | Cytotoxicity: HUVEC: IC50=6.20±0.07 µM AHDF: IC50=6.49±0.13 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
FASEB J. 2019 May 33(5):6470-6482