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Peptide record

TPDB25038

penetratin Antibacterial Anticancer Antifungal Antiparasitic Cell-penetrating Peptides standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB25038
penetratin
Antibacterial Anticancer Antifungal Antiparasitic Cell-penetrating Peptides
Anti-infective peptides Cancer-related peptides Delivery and barrier-penetrating peptides
Peptipedia CPPsite3.0 PerseuCPP
standard
No
A 17-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, CPPsite3.0, and PerseuCPP, with an available 3D structural model.
C-terminal: Conjugated with FAM via Lysine residue Chemical: (G3) PAMAM dendrimer nanoparticles.
Sequence
RQIKIWFQNRRMKWKKK
Physicochemical Analysis
C110H180N36O21S1
ADCEGHLPSTYV
K
2374.93
12.72
8
0
6
+8
3.28
-1.859
45.88
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
11000
463.17
3
Residue Composition
number
0
A
3
R
1
N
0
D
0
C
0
E
2
Q
0
G
0
H
2
I
0
L
5
K
1
M
1
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 1 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 0 I: 2 L: 0 K: 5 M: 1 F: 1 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
17
C110H180N36O21S1
2374.93
12.72
+8
3.28
-1.859
Conjugated with FAM via Lysine residue
(G3) PAMAM dendrimer nanoparticles.
L
Linear
Free
N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Nhc And Sdhcec Cells

Assay & Model

Male Sprague−Dawley rats (17 weeks old)
Male Sprague−Dawley rats (17 weeks old)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
pRFP and FAM dye
Cytoplasm and Lysosomes
Fluorescence in the posterior segments of the eyes treated by pRFP/PAMAM/ P20 was obviously stronger than that treated by pRFP/P20, while nude plasmid-treated eyes revealed no fluorescence distributed in either the cornea or retina
In vitro and in vivo
CCSSSTTCCCCCCC
Additional Detail Fields 1 fields
CCSSSTTCCCCCCC