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Peptide record

TPDB25005

Antibacterial Anticancer Antifungal Antiparasitic Antiviral standard

61 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB25005

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

Peptipedia Antifungipept

Sequence_Type

standard

Has_Modification No

Description A 61-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia and Antifungipept, with an available 3D structural model.

Sequence

RMRRSKSGKGSGGSKGSGSKGSKGSKGSGSKGSGSKGGSRPGGGSSIAGGGSKGKGGTQTA

FASTA

>TPDB25005|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral|length=61
RMRRSKSGKGSGGSKGSGSKGSKGSKGSGSKGSGSKGGSRPGGGSSIAGGGSKGKGGTQTA

Formula C213H378N84O81S1

Absent Amino Acids NDCEHLFWYV

Common Amino Acids G

Mass 5443.92

PI 12.90

Basic Residues 14

Acidic Residues 0

Hydrophobic Residues 4

Net Charge +14

Boman Index 15.88

Hydrophobicity -1.238

Aliphatic Index 9.67

Half Life

Mammalian: 1 hour Yeast: 2 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 19

number

Amino Acid Distribution

A: 2 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 23 H: 0 I: 1 L: 0 K: 10 M: 1 F: 0 P: 1 S: 16 T: 2 W: 0 Y: 0 V: 0

Length

Formula

C213H378N84O81S1

Mass

5443.92

12.90

Net Charge

+14

Boman Index

15.88

Hydrophobicity

-1.238

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 12.5 µg/mL

Target

Target Organism L. anguillarum

Source & Reference

Database Source NA

Other

Evidence Text

Active against Gram-negative L. anguillarum (MIC 12.5 ug/ml), A. salmonicida (MIC 50 ug/ml), V. alginolyticus (MIC 5.2 ug/ml), A. hydrophila (MIC 1.5

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 50 µg/mL

Target

Target Organism A. salmonicida

Source & Reference

Database Source NA

Other

Evidence Text

Active against Gram-negative L. anguillarum (MIC 12.5 ug/ml), A. salmonicida (MIC 50 ug/ml), V. alginolyticus (MIC 5.2 ug/ml), A. hydrophila (MIC 1.5 ug/ml), P. aeruginosa (MIC 12.5

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 5.2 µg/mL

Target

Target Organism V. alginolyticus

Source & Reference

Database Source NA

Other

Evidence Text

ive against Gram-negative L. anguillarum (MIC 12.5 ug/ml), A. salmonicida (MIC 50 ug/ml), V. alginolyticus (MIC 5.2 ug/ml), A. hydrophila (MIC 1.5 ug/ml), P. aeruginosa (MIC 12.5 ug/ml), E. ictaluri (MIC 25 ug/ml

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.5 µg/mL

Target

Target Organism A. hydrophila

Source & Reference

Database Source NA

Other

Evidence Text

llarum (MIC 12.5 ug/ml), A. salmonicida (MIC 50 ug/ml), V. alginolyticus (MIC 5.2 ug/ml), A. hydrophila (MIC 1.5 ug/ml), P. aeruginosa (MIC 12.5 ug/ml), E. ictaluri (MIC 25 ug/ml), E. coli BL21 (MIC 100 ug/ml)

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 12.5 µg/mL

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source NA

Other

Evidence Text

monicida (MIC 50 ug/ml), V. alginolyticus (MIC 5.2 ug/ml), A. hydrophila (MIC 1.5 ug/ml), P. aeruginosa (MIC 12.5 ug/ml), E. ictaluri (MIC 25 ug/ml), E. coli BL21 (MIC 100 ug/ml), V. parahaemolyticus (MIC 25 ug

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 25 µg/mL

Target

Target Organism E. ictaluri

Source & Reference

Database Source NA

Other

Evidence Text

nolyticus (MIC 5.2 ug/ml), A. hydrophila (MIC 1.5 ug/ml), P. aeruginosa (MIC 12.5 ug/ml), E. ictaluri (MIC 25 ug/ml), E. coli BL21 (MIC 100 ug/ml), V. parahaemolyticus (MIC 25 ug/ml), V. harveyi (MIC 6.2 ug

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 100 µg/mL

Target

Target Organism Escherichia coli BL21

Source & Reference

Database Source NA

Other

Evidence Text

. hydrophila (MIC 1.5 ug/ml), P. aeruginosa (MIC 12.5 ug/ml), E. ictaluri (MIC 25 ug/ml), E. coli BL21 (MIC 100 ug/ml), V. parahaemolyticus (MIC 25 ug/ml), V. harveyi (MIC 6.2 ug/ml), V. vulnificus (MIC 100 u

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 25 µg/mL

Target

Target Organism V. parahaemolyticus

Source & Reference

Database Source NA

Other

Evidence Text

P. aeruginosa (MIC 12.5 ug/ml), E. ictaluri (MIC 25 ug/ml), E. coli BL21 (MIC 100 ug/ml), V. parahaemolyticus (MIC 25 ug/ml), V. harveyi (MIC 6.2 ug/ml), V. vulnificus (MIC 100 ug/ml), and V. fluvialis (MIC 3.1 ug/

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6.2 µg/mL

Target

Target Organism V. harveyi

Source & Reference

Database Source NA

Other

Evidence Text

ctaluri (MIC 25 ug/ml), E. coli BL21 (MIC 100 ug/ml), V. parahaemolyticus (MIC 25 ug/ml), V. harveyi (MIC 6.2 ug/ml), V. vulnificus (MIC 100 ug/ml), and V. fluvialis (MIC 3.1 ug/ml).

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 100 µg/mL

Target

Target Organism V. vulnificus

Source & Reference

Database Source NA

Other

Evidence Text

oli BL21 (MIC 100 ug/ml), V. parahaemolyticus (MIC 25 ug/ml), V. harveyi (MIC 6.2 ug/ml), V. vulnificus (MIC 100 ug/ml), and V. fluvialis (MIC 3.1 ug/ml).

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3.1 µg/mL

Target

Target Organism V. fluvialis

Source & Reference

Database Source NA

Other

Evidence Text

emolyticus (MIC 25 ug/ml), V. harveyi (MIC 6.2 ug/ml), V. vulnificus (MIC 100 ug/ml), and V. fluvialis (MIC 3.1 ug/ml).

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 12.5 µg/mL

Target

Target Organism L. anguillarum

Source & Reference

Database Source Antifungipept

Other

Evidence Text

Active against Gram-negative L. anguillarum (MIC 12.5 ug/ml), A. salmonicida (MIC 50 ug/ml), V. alginolyticus (MIC 5.2 ug/ml), A. hydrophila (MIC 1.5

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 50 µg/mL

Target

Target Organism A. salmonicida

Source & Reference

Database Source Antifungipept

Other

Evidence Text

Active against Gram-negative L. anguillarum (MIC 12.5 ug/ml), A. salmonicida (MIC 50 ug/ml), V. alginolyticus (MIC 5.2 ug/ml), A. hydrophila (MIC 1.5 ug/ml), P. aeruginosa (MIC 12.5

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 5.2 µg/mL

Target

Target Organism V. alginolyticus

Source & Reference

Database Source Antifungipept

Other

Evidence Text

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.5 µg/mL

Target

Target Organism A. hydrophila

Source & Reference

Database Source Antifungipept

Other

Evidence Text

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 12.5 µg/mL

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source Antifungipept

Other

Evidence Text

Evidence 17 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 25 µg/mL

Target

Target Organism E. ictaluri

Source & Reference

Database Source Antifungipept

Other

Evidence Text

Evidence 18 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 100 µg/mL

Target

Target Organism Escherichia coli BL21

Source & Reference

Database Source Antifungipept

Other

Evidence Text

Evidence 19 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 25 µg/mL

Target

Target Organism V. parahaemolyticus

Source & Reference

Database Source Antifungipept

Other

Evidence Text

Evidence 20 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 6.2 µg/mL

Target

Target Organism V. harveyi

Source & Reference

Database Source Antifungipept

Other

Evidence Text

ctaluri (MIC 25 ug/ml), E. coli BL21 (MIC 100 ug/ml), V. parahaemolyticus (MIC 25 ug/ml), V. harveyi (MIC 6.2 ug/ml), V. vulnificus (MIC 100 ug/ml), and V. fluvialis (MIC 3.1 ug/ml).

Evidence 21 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 100 µg/mL

Target

Target Organism V. vulnificus

Source & Reference

Database Source Antifungipept

Other

Evidence Text

oli BL21 (MIC 100 ug/ml), V. parahaemolyticus (MIC 25 ug/ml), V. harveyi (MIC 6.2 ug/ml), V. vulnificus (MIC 100 ug/ml), and V. fluvialis (MIC 3.1 ug/ml).

Evidence 22 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 3.1 µg/mL

Target

Target Organism V. fluvialis

Source & Reference

Database Source Antifungipept

Other

Evidence Text

emolyticus (MIC 25 ug/ml), V. harveyi (MIC 6.2 ug/ml), V. vulnificus (MIC 100 ug/ml), and V. fluvialis (MIC 3.1 ug/ml).

Evidence 23 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 12.5 µg/mL

Target

Target Organism L. anguillarum

Source & Reference

Database Source NA

Other

Evidence Text

Active against Gram-negative L. anguillarum (MIC 12.5 ug/ml), A. salmonicida (MIC 50 ug/ml), V. alginolyticus (MIC 5.2 ug/ml), A. hydrophila (MIC 1.5

Evidence 24 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 50 µg/mL

Target

Target Organism A. salmonicida

Source & Reference

Database Source NA

Other

Evidence Text

Active against Gram-negative L. anguillarum (MIC 12.5 ug/ml), A. salmonicida (MIC 50 ug/ml), V. alginolyticus (MIC 5.2 ug/ml), A. hydrophila (MIC 1.5 ug/ml), P. aeruginosa (MIC 12.5

Evidence 25 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 5.2 µg/mL

Target

Target Organism V. alginolyticus

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 26 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 1.5 µg/mL

Target

Target Organism A. hydrophila

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 27 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 12.5 µg/mL

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 28 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 25 µg/mL

Target

Target Organism E. ictaluri

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 29 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 100 µg/mL

Target

Target Organism Escherichia coli BL21

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 30 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 25 µg/mL

Target

Target Organism V. parahaemolyticus

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 31 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 6.2 µg/mL

Target

Target Organism V. harveyi

Source & Reference

Database Source NA

Other

Evidence Text

ctaluri (MIC 25 ug/ml), E. coli BL21 (MIC 100 ug/ml), V. parahaemolyticus (MIC 25 ug/ml), V. harveyi (MIC 6.2 ug/ml), V. vulnificus (MIC 100 ug/ml), and V. fluvialis (MIC 3.1 ug/ml).

Evidence 32 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 100 µg/mL

Target

Target Organism V. vulnificus

Source & Reference

Database Source NA

Other

Evidence Text

oli BL21 (MIC 100 ug/ml), V. parahaemolyticus (MIC 25 ug/ml), V. harveyi (MIC 6.2 ug/ml), V. vulnificus (MIC 100 ug/ml), and V. fluvialis (MIC 3.1 ug/ml).

Evidence 33 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 3.1 µg/mL

Target

Target Organism V. fluvialis

Source & Reference

Database Source NA

Other

Evidence Text

emolyticus (MIC 25 ug/ml), V. harveyi (MIC 6.2 ug/ml), V. vulnificus (MIC 100 ug/ml), and V. fluvialis (MIC 3.1 ug/ml).

Evidence 34 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 12.5 µg/mL

Target

Target Organism L. anguillarum

Source & Reference

Database Source NA

Other

Evidence Text

Active against Gram-negative L. anguillarum (MIC 12.5 ug/ml), A. salmonicida (MIC 50 ug/ml), V. alginolyticus (MIC 5.2 ug/ml), A. hydrophila (MIC 1.5

Evidence 35 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 50 µg/mL

Target

Target Organism A. salmonicida

Source & Reference

Database Source NA

Other

Evidence Text

Active against Gram-negative L. anguillarum (MIC 12.5 ug/ml), A. salmonicida (MIC 50 ug/ml), V. alginolyticus (MIC 5.2 ug/ml), A. hydrophila (MIC 1.5 ug/ml), P. aeruginosa (MIC 12.5

Evidence 36 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 5.2 µg/mL

Target

Target Organism V. alginolyticus

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 37 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 1.5 µg/mL

Target

Target Organism A. hydrophila

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 38 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 12.5 µg/mL

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 39 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 25 µg/mL

Target

Target Organism E. ictaluri

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 40 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 100 µg/mL

Target

Target Organism Escherichia coli BL21

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 41 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 25 µg/mL

Target

Target Organism V. parahaemolyticus

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 42 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 6.2 µg/mL

Target

Target Organism V. harveyi

Source & Reference

Database Source NA

Other

Evidence Text

ctaluri (MIC 25 ug/ml), E. coli BL21 (MIC 100 ug/ml), V. parahaemolyticus (MIC 25 ug/ml), V. harveyi (MIC 6.2 ug/ml), V. vulnificus (MIC 100 ug/ml), and V. fluvialis (MIC 3.1 ug/ml).

Evidence 43 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 100 µg/mL

Target

Target Organism V. vulnificus

Source & Reference

Database Source NA

Other

Evidence Text

oli BL21 (MIC 100 ug/ml), V. parahaemolyticus (MIC 25 ug/ml), V. harveyi (MIC 6.2 ug/ml), V. vulnificus (MIC 100 ug/ml), and V. fluvialis (MIC 3.1 ug/ml).

Evidence 44 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 3.1 µg/mL

Target

Target Organism V. fluvialis

Source & Reference

Database Source NA

Other

Evidence Text

emolyticus (MIC 25 ug/ml), V. harveyi (MIC 6.2 ug/ml), V. vulnificus (MIC 100 ug/ml), and V. fluvialis (MIC 3.1 ug/ml).