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Peptide record

TPDB24959

Antibacterial Anticancer Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB24959
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
standard
No
A 20-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
RLIKRIKTWYRKAWKVVGKF
Physicochemical Analysis
C125H202N36O23
NDCEQHMPS
K
2577.21
12.17
8
0
10
+8
0.55
-0.570
92.50
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
12490
484.63
2
Residue Composition
number
1
A
3
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
2
I
1
L
5
K
0
M
1
F
0
P
0
S
1
T
2
W
1
Y
2
V
Amino Acid Distribution
A: 1 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 2 L: 1 K: 5 M: 0 F: 1 P: 0 S: 0 T: 1 W: 2 Y: 1 V: 2
Chemical Descriptors
20
C125H202N36O23
2577.21
12.17
+8
0.55
-0.570
Evidence Records 3 records
Evidence 1 Activity

Activity

EC50
Toxicity
23±5 µM
Cytotoxic
EC50 | 23±5 | µM | target cell: Human dermal microvascular endothelial cells HDME

Target

Human dermal microvascular endothelial cells HDME

Source & Reference

NA
DBAASP
In silico design and optimization of selective membranolytic anticancer peptides. | Sci Rep | 2019
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
>200 µM
Hemolytic Cytotoxic
50% Hemolysis | >200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
In silico design and optimization of selective membranolytic anticancer peptides. | Sci Rep | 2019
Evidence 3 Activity

Activity

HC50
Toxicity
200 µM
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: HC50>200 µM | Cytotoxicity: HDMEC: EC50=23 ± 5 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Sci Rep. 2019 Aug 2 9(1):11282.