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Peptide record

TPDB24924

Antibacterial Anticancer Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB24924
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CancerPPD 2.0
standard
No
A 14-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia and CancerPPD 2.0, with an available 3D structural model.
Sequence
RLLRLLRLRRLLRL
Physicochemical Analysis
C84H162N32O15
ANDCEQGHIKMFPSTWYV
L
1860.42
13.10
6
0
8
+6
0.38
0.243
222.86
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
8
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 8 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
14
C84H162N32O15
1860.42
13.10
+6
0.38
0.243
Evidence Records 4 records
Evidence 1 Activity

Activity

IC50
Toxicity
21.4±1.3 µM
Cytotoxic
IC50 | 21.4±1.3 | µM | target cell: Human Lung Fibroblasts

Target

Human Lung Fibroblasts

Source & Reference

NA
DBAASP
Amphipathicity Determines Different Cytotoxic Mechanisms of Lysine- or Arginine-Rich Cationic Hydrophobic Peptides in Cancer Cells. | J Med Chem | 2016
Evidence 2 Activity

Activity

IC50
Toxicity
41.6±2.7 µM
Cytotoxic
IC50 | 41.6±2.7 | µM | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Amphipathicity Determines Different Cytotoxic Mechanisms of Lysine- or Arginine-Rich Cationic Hydrophobic Peptides in Cancer Cells. | J Med Chem | 2016
Evidence 3 Activity

Activity

IC50
Toxicity
19±1.5 µM
Cytotoxic
IC50 | 19±1.5 | µM | target cell: Human umbilical vein endothelial cells HUVEC

Target

Human umbilical vein endothelial cells HUVEC

Source & Reference

NA
DBAASP
Amphipathicity Determines Different Cytotoxic Mechanisms of Lysine- or Arginine-Rich Cationic Hydrophobic Peptides in Cancer Cells. | J Med Chem | 2016
Evidence 4 Activity

Activity

HD50
Toxicity
200 µM
Hemolytic Cytotoxic
Hemolytic_activity: Mice red blood cells: HD50>200 µM | Cytotoxicity: HLF: IC50=21.4±1.3 µM 293T: IC50=41.6±2.7 µM HUVEC: IC50=19±1.5 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
J Med Chem. 2016 Jun 9 59(11):5238-47.