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Peptide record

TPDB24906

Antibacterial Antifungal Toxicity standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB24906
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia CAFPdb dbAMP
standard
No
A 6-aa standard-residue multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from Peptipedia, CAFPdb, and dbAMP, with an available 3D structural model.
Sequence
RKKWFA
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C41H62N12O7
NDCEQGHILMPSTYV
K
835.02
11.64
3
0
3
+3
3.15
-1.433
16.67
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
5500
6.59
0
Residue Composition
number
1
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
2
K
0
M
1
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 2 M: 0 F: 1 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
6 reviewed residue count
C41H62N12O7 sequence-only estimate (linear, free termini)
835.02 sequence-only estimate (linear, free termini)
11.64 sequence-only estimate (linear, free termini)
+3 sequence-only estimate (linear, free termini)
3.15 sequence-only estimate (linear, free termini)
-1.433 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
Antibacterial
3.7 µM

Target

P. digitatum

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
inhibited fungus P. digitatum (IC50 3.7 uM) cf WT (IC50 2.2 uM).
Evidence 2 Activity

Activity

IC50
Antifungal
3.7 µM

Target

P. digitatum

Source & Reference

dbAMP CAFPdb

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
inhibited fungus P. digitatum (IC50 3.7 uM) cf WT (IC50 2.2 uM).