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Peptide record

TPDB24903

Antibacterial Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB24903
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
standard
No
A 16-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
RIKTRTWRLALRWLKL
Physicochemical Analysis
C99H168N32O19
NDCEQGHMFPSYV
RL
2110.63
12.88
6
0
8
+6
-0.92
-0.469
128.12
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
11000
521.17
2
Residue Composition
number
1
A
4
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
4
L
2
K
0
M
0
F
0
P
0
S
2
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 4 K: 2 M: 0 F: 0 P: 0 S: 0 T: 2 W: 2 Y: 0 V: 0
Chemical Descriptors
16
C99H168N32O19
2110.63
12.88
+6
-0.92
-0.469
Evidence Records 6 records
Evidence 1 Activity

Activity

MIC
Antibacterial
3.70-14.81 µM

Target

Staphylococcus aureus ATCC 25923 or ATCC 6538 or RN 4220 or MRSA ATCC 43300 or ATCC 16558

Source & Reference

NA

Other

active against S. aureus ATCC 25923 or ATCC 6538 or RN 4220 or MRSA ATCC 43300 or ATCC 16558 (MIC 3.70-14.81 uM), L. monocytogenes ATCC 19115 (MIC 0.93 uM), B. subtilis ATCC 6633 (MIC 0.93 uM). MBC are
Evidence 2 Activity

Activity

MIC
Antibacterial
0.93 µM

Target

L. monocytogenes ATCC 19115

Source & Reference

NA

Other

ATCC 25923 or ATCC 6538 or RN 4220 or MRSA ATCC 43300 or ATCC 16558 (MIC 3.70-14.81 uM), L. monocytogenes ATCC 19115 (MIC 0.93 uM), B. subtilis ATCC 6633 (MIC 0.93 uM). MBC are higher. Gram- bacteria were not tested. cf.
Evidence 3 Activity

Activity

MIC
Antibacterial
0.93 µM

Target

B. subtilis ATCC 6633

Source & Reference

NA

Other

ATCC 43300 or ATCC 16558 (MIC 3.70-14.81 uM), L. monocytogenes ATCC 19115 (MIC 0.93 uM), B. subtilis ATCC 6633 (MIC 0.93 uM). MBC are higher. Gram- bacteria were not tested. cf. nisin is not active against these st
Evidence 4 Activity

Activity

45% Hemolysis
Toxicity
64 µM
Hemolytic Cytotoxic
45% Hemolysis | 64 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Combating Escherichia coli O157:H7 with Functionalized Chickpea-Derived Antimicrobial Peptides. | Adv Sci (Weinh) | 2022
Evidence 5 Activity

Activity

16.3% Cytotoxicity
Toxicity
640 µg/mL
Cytotoxic
16.3% Cytotoxicity | 640 | µg/mL | target cell: Human hepatocyte cells HL-7702 (L02)

Target

Human hepatocyte cells HL-7702 (L02)

Source & Reference

NA
DBAASP
Combating Escherichia coli O157:H7 with Functionalized Chickpea-Derived Antimicrobial Peptides. | Adv Sci (Weinh) | 2022
Evidence 6 Activity

Activity

19% Cytotoxicity
Toxicity
640 µg/mL
Cytotoxic
19% Cytotoxicity | 640 | µg/mL | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Combating Escherichia coli O157:H7 with Functionalized Chickpea-Derived Antimicrobial Peptides. | Adv Sci (Weinh) | 2022