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Peptide record

TPDB24900

Antibacterial Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB24900
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
standard
No
A 12-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
RIKRLALRWLKL
Physicochemical Analysis
C74H132N24O13
NDCEQGHMFPSTYV
L
1566.01
12.71
5
0
7
+5
-0.16
-0.058
170.83
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
5500
351.21
0
Residue Composition
number
1
A
3
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
4
L
2
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 4 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
12
C74H132N24O13
1566.01
12.71
+5
-0.16
-0.058
Evidence Records 3 records
Evidence 1 Activity

Activity

20% Hemolysis
Toxicity
64 µM
Hemolytic Cytotoxic
20% Hemolysis | 64 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Combating Escherichia coli O157:H7 with Functionalized Chickpea-Derived Antimicrobial Peptides. | Adv Sci (Weinh) | 2022
Evidence 2 Activity

Activity

16% Cytotoxicity
Toxicity
640 µg/mL
Cytotoxic
16% Cytotoxicity | 640 | µg/mL | target cell: Human hepatocyte cells HL-7702 (L02)

Target

Human hepatocyte cells HL-7702 (L02)

Source & Reference

NA
DBAASP
Combating Escherichia coli O157:H7 with Functionalized Chickpea-Derived Antimicrobial Peptides. | Adv Sci (Weinh) | 2022
Evidence 3 Activity

Activity

15% Cytotoxicity
Toxicity
640 µg/mL
Cytotoxic
15% Cytotoxicity | 640 | µg/mL | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Combating Escherichia coli O157:H7 with Functionalized Chickpea-Derived Antimicrobial Peptides. | Adv Sci (Weinh) | 2022