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Peptide record

TPDB24892

Antibacterial Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB24892
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
standard
No
A 14-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
RKGCKCKNGFCVCR
Physicochemical Analysis
C64H112N24O16S4
ADEQHILMPSTWY
C
1601.98
9.83
5
0
2
+5
3.01
-0.571
20.71
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
250
15.61
5
Residue Composition
number
0
A
2
R
1
N
0
D
4
C
0
E
0
Q
2
G
0
H
0
I
0
L
3
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 2 N: 1 D: 0 C: 4 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 3 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
14
C64H112N24O16S4
1601.98
9.83
+5
3.01
-0.571
Evidence Records 3 records
Evidence 1 Activity

Activity

18% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
18% Hemolysis | 25 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
An insect defensin-derived β-hairpin peptide with enhanced antibacterial activity. | ACS Chem Biol | 2014
Evidence 2 Activity

Activity

25% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
25% Hemolysis | 50 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
An insect defensin-derived β-hairpin peptide with enhanced antibacterial activity. | ACS Chem Biol | 2014
Evidence 3 Activity

Activity

20% Hemolysis
Toxicity
25-50 µM
Hemolytic Cytotoxic
20% Hemolysis | 25-50 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
An insect defensin-derived β-hairpin peptide with enhanced antibacterial activity. | ACS Chem Biol | 2014