TPDB

3D PDB MODEL

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TPDB ID TPDB24880

Activity

Antibacterial Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 16-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

RKIIAVSVHKLCRVKR

FASTA

>TPDB24880|Antibacterial;Toxicity|length=16
RKIIAVSVHKLCRVKR

Formula C84H156N30O18S1

Absent Amino Acids NDEQGMFPTWY

Common Amino Acids RKV

Mass 1906.41

PI 12.14

Basic Residues 7

Acidic Residues 0

Hydrophobic Residues 7

Net Charge +6

Boman Index 5.11

Hydrophobicity 0.031

Aliphatic Index 133.75

Half Life

Mammalian: 1 hour Yeast: 2 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 2

number

1

A

3

R

0

N

0

D

1

C

0

E

0

Q

0

G

1

H

2

I

1

L

3

K

0

M

0

F

0

P

1

S

0

T

0

W

0

Y

3

V

Amino Acid Distribution

A: 1 R: 3 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 0 H: 1 I: 2 L: 1 K: 3 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 3

Length

16

Formula

C84H156N30O18S1

Mass

1906.41

PI

12.14

Net Charge

+6

Boman Index

5.11

Hydrophobicity

0.031

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 64-128 µg/mL

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli ATCC 25922 (MIC 64-128 ug/ml), S. enteritidis (MIC 64 ug/ml), and S.aureus ATCC 29213 (MIC >128 ug/ml).

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 64 µg/mL

Target

Target Organism S. enteritidis

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli ATCC 25922 (MIC 64-128 ug/ml), S. enteritidis (MIC 64 ug/ml), and S.aureus ATCC 29213 (MIC >128 ug/ml).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >128 µg/mL

Target

Target Organism S.aureus ATCC 29213

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli ATCC 25922 (MIC 64-128 ug/ml), S. enteritidis (MIC 64 ug/ml), and S.aureus ATCC 29213 (MIC >128 ug/ml).

Evidence 4 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement >128 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | >128 | µg/mL | target cell: Pig erythrocytes

Target

Target Cell Pig erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Associating Biological Activity and Predicted Structure of Antimicrobial Peptides from Amphibians and Insects. | Antibiotics (Basel) | 2022