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Peptide record

TPDB24854

Antibacterial Antifungal Hemolysis Toxicity standard
4 amino acids
Basic Information
3D PDB MODEL
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TPDB24854
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia CAFPdb dbAMP PD_Hemolysis
standard
No
A 4-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from Peptipedia, CAFPdb, dbAMP, and other sources, with an available 3D structural model.
Sequence
RIWR
Physicochemical Analysis
C29H47N11O5
ANDCEQGHLKMFPSTYV
R
629.76
12.40
2
0
2
+2
-0.54
-1.350
97.50
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
5500
873.34
0
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
4
C29H47N11O5
629.76
12.40
+2
-0.54
-1.350
Evidence Records 7 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
50 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 50 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design, antimicrobial activity and mechanism of action of Arg-rich ultra-short cationic lipopeptides. | PLoS One | 2019
Evidence 2 Activity

Activity

100% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
100% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design, antimicrobial activity and mechanism of action of Arg-rich ultra-short cationic lipopeptides. | PLoS One | 2019
Evidence 3 Activity

Activity

30-40% Killing
Toxicity
100 µg/mL
Cytotoxic
30-40% Killing | 100 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Design, antimicrobial activity and mechanism of action of Arg-rich ultra-short cationic lipopeptides. | PLoS One | 2019
Evidence 4 Activity

Activity

<3% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
<3% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Effects of Lipidation on a Proline-Rich Antibacterial Peptide. | Int J Mol Sci | 2021
Evidence 5 Activity

Activity

42% Cytotoxicity
Toxicity
25 µM
Cytotoxic
42% Cytotoxicity | 25 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Effects of Lipidation on a Proline-Rich Antibacterial Peptide. | Int J Mol Sci | 2021
Evidence 6 Activity

Activity

98% Cytotoxicity
Toxicity
100 µM
Cytotoxic
98% Cytotoxicity | 100 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Effects of Lipidation on a Proline-Rich Antibacterial Peptide. | Int J Mol Sci | 2021
Evidence 7 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis