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Peptide record

TPDB24843

Antibacterial Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB24843
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
standard
No
A 12-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
RIRIRRRFIRIR
Physicochemical Analysis
C75H139N33O13
ANDCEQGHLKMPSTWYV
R
1711.14
13.18
7
0
5
+7
3.30
-0.892
130.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
7
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
4
I
0
L
0
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 7 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 4 L: 0 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
12
C75H139N33O13
1711.14
13.18
+7
3.30
-0.892
Evidence Records 2 records
Evidence 1 Activity

Activity

10% Hemolysis
Toxicity
>256 µM
Hemolytic Cytotoxic
10% Hemolysis | >256 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance. | J Med Chem | 2022
Evidence 2 Activity

Activity

IC 50
Toxicity
>128 µM
Cytotoxic
IC 50 | >128 | µM | target cell: Human kidney proximal tubule HK-2 cells

Target

Human kidney proximal tubule HK-2 cells

Source & Reference

NA
DBAASP
Novel β-Hairpin Antimicrobial Peptides Containing the β-Turn Sequence of -RRRF- Having High Cell Selectivity and Low Incidence of Drug Resistance. | J Med Chem | 2022