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Peptide record

TPDB24822

Antibacterial Antifungal Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB24822
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia CAFPdb dbAMP
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from Peptipedia, CAFPdb, and dbAMP, with an available 3D structural model.
Sequence
RIGRFLLFRGIRRIGRFL
Physicochemical Analysis
C105H176N36O19
ANDCEQHKMPSTWYV
R
2246.78
13.10
6
0
9
+6
-1.11
0.283
130.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
0
E
0
Q
3
G
0
H
3
I
3
L
0
K
0
M
3
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 3 L: 3 K: 0 M: 0 F: 3 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
18
C105H176N36O19
2246.78
13.10
+6
-1.11
0.283
Evidence Records 5 records
Evidence 1 Activity

Activity

<5% Hemolysis
Toxicity
64 µM
Hemolytic Cytotoxic
<5% Hemolysis | 64 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A Novel Dual-Targeted α-Helical Peptide With Potent Antifungal Activity Against Fluconazole-Resistant Candida albicans Clinical Isolates. | Front Microbiol | 2020
Evidence 2 Activity

Activity

5% Killing
Toxicity
32 µM
Cytotoxic
5% Killing | 32 | µM | target cell: Intestinal Porcine Epithelial Cells IPEC-J2

Target

Intestinal Porcine Epithelial Cells IPEC-J2

Source & Reference

NA
DBAASP
A Novel Dual-Targeted α-Helical Peptide With Potent Antifungal Activity Against Fluconazole-Resistant Candida albicans Clinical Isolates. | Front Microbiol | 2020
Evidence 3 Activity

Activity

60% Killing
Toxicity
64 µM
Cytotoxic
60% Killing | 64 | µM | target cell: Intestinal Porcine Epithelial Cells IPEC-J2

Target

Intestinal Porcine Epithelial Cells IPEC-J2

Source & Reference

NA
DBAASP
A Novel Dual-Targeted α-Helical Peptide With Potent Antifungal Activity Against Fluconazole-Resistant Candida albicans Clinical Isolates. | Front Microbiol | 2020
Evidence 4 Activity

Activity

10% Killing
Toxicity
32 µM
Cytotoxic
10% Killing | 32 | µM | target cell: Porcine mammary epithelial cells PMEC

Target

Porcine mammary epithelial cells PMEC

Source & Reference

NA
DBAASP
A Novel Dual-Targeted α-Helical Peptide With Potent Antifungal Activity Against Fluconazole-Resistant Candida albicans Clinical Isolates. | Front Microbiol | 2020
Evidence 5 Activity

Activity

68% Killing
Toxicity
64 µM
Cytotoxic
68% Killing | 64 | µM | target cell: Porcine mammary epithelial cells PMEC

Target

Porcine mammary epithelial cells PMEC

Source & Reference

NA
DBAASP
A Novel Dual-Targeted α-Helical Peptide With Potent Antifungal Activity Against Fluconazole-Resistant Candida albicans Clinical Isolates. | Front Microbiol | 2020