TPDB

3D PDB MODEL

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TPDB ID TPDB24748

Activity

Antibacterial Anticancer Antifungal Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

Peptipedia AFP-GFuse

Sequence_Type

standard

Has_Modification No

Description A 16-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia and AFP-GFuse, with an available 3D structural model.

Sequence

RGDILKRWAGHFSKLL

FASTA

>TPDB24748|Antibacterial;Anticancer;Antifungal;Toxicity|length=16
RGDILKRWAGHFSKLL

Formula C88H141N27O20

Absent Amino Acids NCEQMPTYV

Common Amino Acids L

Mass 1897.26

PI 11.47

Basic Residues 5

Acidic Residues 1

Hydrophobic Residues 7

Net Charge +3

Boman Index 0.80

Hydrophobicity -0.344

Aliphatic Index 103.75

Half Life

Mammalian: 1 hour Yeast: 2 min E.coli: 2 min

Extinction Coefficient Cystines 5500

Absorbance 280nm 289.89

Polar Residues 1

number

1

A

2

R

0

N

1

D

0

C

0

E

0

Q

2

G

1

H

1

I

3

L

2

K

0

M

1

F

0

P

1

S

0

T

1

W

0

Y

0

V

Amino Acid Distribution

A: 1 R: 2 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 2 H: 1 I: 1 L: 3 K: 2 M: 0 F: 1 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 0

Length

16

Formula

C88H141N27O20

Mass

1897.26

PI

11.47

Net Charge

+3

Boman Index

0.80

Hydrophobicity

-0.344

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 26.4-52.7 µM

Target

Target Organism Candida albicans clinical resistant strains

Source & Reference

Database Source NA

Other

Evidence Text

ainst C. albicans AY93025, C. albicans ATCC 10231, C. albicans CMCC 98001, C. albicans, 5 C. albicans clinical resistant strains (MIC 26.4-52.7 uM). It reduced biofilms as well.

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 26.4-52.7 µM

Target

Target Organism Candida albicans clinical resistant strains

Source & Reference

Database Source NA

Other

Evidence Text

ainst C. albicans AY93025, C. albicans ATCC 10231, C. albicans CMCC 98001, C. albicans, 5 C. albicans clinical resistant strains (MIC 26.4-52.7 uM). It reduced biofilms as well.

Evidence 3 Activity

Activity

Activity Endpoint <5% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 400 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

<5% Hemolysis | 400 | µg/mL | target cell: Mouse erythrocytes

Target

Target Cell Mouse erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

In vitro and in vivo Activity of Phibilin Against Candida albicans. | Front Microbiol | 2022

Evidence 4 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Cytotoxic

Toxicity Raw

NA | target cell: Human embryonic kidney HEK293T cells

Target

Target Cell Human embryonic kidney HEK293T cells

Source & Reference

Database Source NA

Source Database DBAASP

Reference

In vitro and in vivo Activity of Phibilin Against Candida albicans. | Front Microbiol | 2022