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Peptide record

TPDB24747

Cilengitide Antibacterial Anticancer Toxicity Tumor-homing Peptides standard
5 amino acids
Basic Information
3D PDB MODEL
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TPDB24747
Cilengitide
Antibacterial Anticancer Toxicity Tumor-homing Peptides
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia TumorHoPe2.0
standard
No
A 5-aa standard natural multi-activity (Antibacterial, Anticancer, Toxicity, and other sources) peptide sequence curated from Peptipedia and TumorHoPe2.0, with an available 3D structural model.
Sequence
RGDFV
Physicochemical Analysis
C26H40N8O8
ANCEQHILKMPSTWY
RDGFV
592.65
6.78
1
1
2
-0
0.99
-0.280
58.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
1
R
0
N
1
D
0
C
0
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
5
C26H40N8O8
592.65
6.78
-0
0.99
-0.280
RGD
Evidence Records 4 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
Lung cancer, Glioblastoma, Prostate cancer

Source & Reference

TumorHoPe2.0
TumorHoPe2
Oncolytic T7 bacteriophage having cytokine gene and displaying homing peptide on capsid and its use for treating melanoma
2022
US 11384338 B2
US 11384338 B2

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
6-week-old female Balb/C mice
Phage display library
T7 phage
RGD-{D-F}-{N-methyl-Val}
Cyclic
Evidence 2 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
Lung cancer, Breast cancer, Liver cancer, Melanoma, stomach cancer, Pancreatic cancer, Colorectal cancer, Ovarian cancer, Renal cell carcinoma, Prostate cancer, Brain tumor

Source & Reference

TumorHoPe2.0
TumorHoPe2
Noxa-derived, cell death-inducing peptide eMTD
2022
US 11248024 B2
US 11248024 B2

Other

Sp2/0, CHO (Chinese hamster ovary) K1, CHO DG44, PER.C6, W138, BHK, COS7, 293, HepG2, Huh7, 3T3, RIN, MDCK cell line
6-week-old BalB/C mice
Synthetic
necrosis-inducing peptide, Fluorescein (FAM)
Evidence 3 Activity

Activity

Tumor-homing Peptides

Target

Targeting

Source & Reference

TumorHoPe2.0
TumorHoPe2
2017
US 9827327 B2
US 9827327 B2

Other

U87 human-derived glioblastoma cell, prostate DU145 carcinoma cells, Human umbilical vein endothelial cells (HUVEC), M21 human melanoma cells
BALB/c nude mice
glycoproteins, FITC
Evidence 4 Activity

Activity

Tumor-homing Peptides

Target

Tumor vessel, Tumor cell, Endothelial cell
Targeting
αvβ3, αvβ5

Source & Reference

TumorHoPe2.0
TumorHoPe2
Methods and compositions related to adenoassociated virus-phage particles
2017
US 9827327 B2
US 9827327 B2

Other

U87 human-derived glioblastoma cell, prostate DU145 carcinoma cells, Human umbilical vein endothelial cells (HUVEC), M21 human melanoma cells
BALB/c nude mice
Synthetic
glycoproteins, FITC
Additional Detail Fields 4 fields
RGD-{D-F}-{N-methyl-Val} necrosis-inducing peptide, Fluorescein (FAM) glycoproteins, FITC
Sp2/0, CHO (Chinese hamster ovary) K1, CHO DG44, PER.C6, W138, BHK, COS7, 293, HepG2, Huh7, 3T3, RIN, MDCK cell line U87 human-derived glioblastoma cell, prostate DU145 carcinoma cells, Human umbilical vein endothelial cells (HUVEC), M21 human melanoma cells
6-week-old female Balb/C mice 6-week-old BalB/C mice BALB/c nude mice
T7 phage