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Peptide record

TPDB24746

cRGD peptide Cyclic-RGDfK Antibacterial Anticancer Cell-penetrating Peptides Tumor-homing Peptides standard
5 amino acids
Basic Information
3D PDB MODEL
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TPDB24746
cRGD peptide Cyclic-RGDfK
Antibacterial Anticancer Cell-penetrating Peptides Tumor-homing Peptides
Anti-infective peptides Cancer-related peptides Delivery and barrier-penetrating peptides
Peptipedia CellPPD-MOD CPPsite3.0 PerseuCPP TumorHoPe2.0
standard
No
A 5-aa standard natural multi-activity (Antibacterial, Anticancer, Cell-penetrating Peptides, and other sources) peptide sequence curated from Peptipedia, CellPPD-MOD, CPPsite3.0, and other sources, with an available 3D structural model.
Sequence
RGDFK
Physicochemical Analysis
C27H43N9O8
ANCEQHILMPSTWYV
RDGKF
621.69
10.09
2
1
1
+1
1.91
-1.900
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
1
R
0
N
1
D
0
C
0
E
0
Q
1
G
0
H
0
I
0
L
1
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 1 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
5
C27H43N9O8
621.69
10.09
+1
1.91
-1.900
RGD
Evidence Records 7 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Endothelial cell, Tumor cell, Tumor vessel
Targeting
Breast cancer, Colon cancer, Pancreatic ductal adenocarcinoma
αvβ6

Source & Reference

TumorHoPe2.0
TumorHoPe2
Nano-enabled immunotherapy in cancer
2022
US 11433143 B2
US 11433143 B2

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
4T1 breast cancer, CT26 colon cancer, pancreatic ductal adenocarcinoma (KPC) cell
BALB/c mice
Phage display library
PEGylated cholesterol , indoximod
Cyclic
Evidence 2 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell, Tumor vessel, Tumor stem cell, Endothelial cell, Epithelial cell, Dendritic cell
Homing
Breast cancer, Colon cancer

Source & Reference

TumorHoPe2.0
TumorHoPe2
Methods and compositions using peptides and proteins with C-terminal elements
2019
US 10370245 B2
US 10370245 B2

Other

PPC-1, PC-3, Du-145, 4T1, MIA PaCa-2, PDAC1.3, B16F10, M21, and MDA-MB-435 cell line
BALB/c athymic nude mice
Phage Display library
T7 phage display library
nanoparticles, nanoworms, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)2000 DSPE-PEG2000-maleimide]
cyclo
Evidence 3 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell, Tumor vessel
Targeting
Glioblastoma
αvβ3 integrin

Source & Reference

TumorHoPe2.0
TumorHoPe2
Molecular Imaging and Preclinical Studies of Radiolabeled Long-Term RGD Peptides in U-87 MG Tumor-Bearing Mice
2021
Wei-Lin Lo et al. Int J Mol Sci. 2021 May 21 22(11):5459.

Other

human glioblastoma cell line U-87 MG
Female non-obese diabetic, severe combined immunodeficiency (NOD/SCID) mice
Synthetic
Indium-111 (111In), Evans blue (EB), DOTA chelator
Cyclic
Evidence 4 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell, Endothelial cell, Tumor vessel
Homing
VEGF, neuropilin-1

Source & Reference

TumorHoPe2.0
TumorHoPe2
Tumor-penetrating peptides
2013
Tambet Teesalu et al. Front Oncol. 2013 Aug 27:3:216.

Other

Phage Display library
doxorubicin
cyclo
Evidence 5 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell, Endothelial cell
Targeting
αvβ3

Source & Reference

TumorHoPe2.0
TumorHoPe2
A Nanosystem of Amphiphilic Oligopeptide-Drug Conjugate Actualizing Both αvβ3 Targeting and Reduction-Triggered Release for Maytansinoid
2017
Yanqin Liang et al. Theranostics. 2017 Jul 23 7(13):3306-3318.

Other

positive melanoma B16 cells, human umbilical vein endothelial cells (HUVEC), MCF-7 cells
C57BL/6 mice
Synthetic
paclitaxel, oleic acid
Cyclic
Evidence 6 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Targeting
Multiple tumor
Integrin

Source & Reference

TumorHoPe2.0
TumorHoPe2
cRGD Peptide-Conjugated Pyropheophorbide-a Photosensitizers for Tumor Targeting in Photodynamic Therapy
2018
Li W et al. Mol Pharm. 2018 Apr 2 15(4):1505-1514.

Other

U87MG, PC3, A431, 4T1
BALB/c nude mice (male and female, 7–8 weeks old)
Synthetic
Pyropheophorbide, Polyethylene glycol
Cyclic
Evidence 7 Activity

Activity

Tumor-homing Peptides

Target

Targeting
Alpha-5 beta- 3 integrins

Source & Reference

TumorHoPe2.0
TumorHoPe2
cRGDfK-Grafted Small-Size Quercetin Micelles For Enhancing Therapy Efficacy Of Active Ingredient From The Chinese Medicinal Herb
2019
Xu P et al. Int J Nanomedicine.2019 Nov 27:14:9173-9184

Other

B16 cell
Male nu/nu mice
Synthetic
DSPE-PEG-NHS
Cyclic, D-phenylalanine
Additional Detail Fields 4 fields
PEGylated cholesterol , indoximod nanoparticles, nanoworms, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)2000 DSPE-PEG2000-maleimide] Indium-111 (111In), Evans blue (EB), DOTA chelator doxorubicin paclitaxel, oleic acid Pyropheophorbide, Polyethylene glycol DSPE-PEG-NHS
4T1 breast cancer, CT26 colon cancer, pancreatic ductal adenocarcinoma (KPC) cell PPC-1, PC-3, Du-145, 4T1, MIA PaCa-2, PDAC1.3, B16F10, M21, and MDA-MB-435 cell line human glioblastoma cell line U-87 MG positive melanoma B16 cells, human umbilical vein endothelial cells (HUVEC), MCF-7 cells U87MG, PC3, A431, 4T1 B16 cell
BALB/c mice BALB/c athymic nude mice Female non-obese diabetic, severe combined immunodeficiency (NOD/SCID) mice C57BL/6 mice BALB/c nude mice (male and female, 7–8 weeks old) Male nu/nu mice
T7 phage display library