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Peptide record

TPDB24740

Antibacterial Antifungal standard
63 amino acids
Basic Information
3D PDB MODEL
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TPDB24740
Antibacterial Antifungal
Anti-infective peptides
Peptipedia Antifungipept
standard
No
A 63-aa standard-residue multi-activity (Antibacterial and Antifungal) peptide sequence curated from Peptipedia and Antifungipept, with an available 3D structural model.
Sequence
RGFRKHFNNLPICVEGLAGDIGSILLGVESDIGALAGAIANLALIAGECAAQGEAGAAVVAAT
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C268H440N76O83S2
MWY
A
6119.02
4.43
4
6
33
-3
-0.06
0.749
121.11
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
125
0.02
9
Residue Composition
number
14
A
2
R
3
N
2
D
2
C
4
E
1
Q
10
G
1
H
6
I
7
L
1
K
0
M
2
F
1
P
2
S
1
T
0
W
0
Y
4
V
Amino Acid Distribution
A: 14 R: 2 N: 3 D: 2 C: 2 E: 4 Q: 1 G: 10 H: 1 I: 6 L: 7 K: 1 M: 0 F: 2 P: 1 S: 2 T: 1 W: 0 Y: 0 V: 4
Chemical Descriptors
63 reviewed residue count
C268H440N76O83S2 sequence-only estimate (linear, free termini)
6119.02 sequence-only estimate (linear, free termini)
4.43 sequence-only estimate (linear, free termini)
-3 sequence-only estimate (linear, free termini)
-0.06 sequence-only estimate (linear, free termini)
0.749 sequence-only estimate (linear, free termini)
Evidence Records 4 records
Evidence 1 Activity

Activity

MIC
Antibacterial
15-30 µg/mL

Target

Escherichia coli

Source & Reference

NA

Other

ted using the recombinant fusion protein with thioredoxin Trx-stomoxynZH1. Active against E. coli (MIC 15-30 ug/ml) and S. aureus (MIC 27-54 ug/ml). There are additional peptides reported without activity
Evidence 2 Activity

Activity

MIC
Antibacterial
27-54 µg/mL

Target

Staphylococcus aureus

Source & Reference

NA

Other

on protein with thioredoxin Trx-stomoxynZH1. Active against E. coli (MIC 15-30 ug/ml) and S. aureus (MIC 27-54 ug/ml). There are additional peptides reported without activity data yet.
Evidence 3 Activity

Activity

MIC
Antifungal
15-30 µg/mL

Target

Escherichia coli

Source & Reference

Antifungipept

Other

ted using the recombinant fusion protein with thioredoxin Trx-stomoxynZH1. Active against E. coli (MIC 15-30 ug/ml) and S. aureus (MIC 27-54 ug/ml). There are additional peptides reported without activity
Evidence 4 Activity

Activity

MIC
Antifungal
27-54 µg/mL

Target

Staphylococcus aureus

Source & Reference

Antifungipept

Other

on protein with thioredoxin Trx-stomoxynZH1. Active against E. coli (MIC 15-30 ug/ml) and S. aureus (MIC 27-54 ug/ml). There are additional peptides reported without activity data yet.