Back to search

Peptide record

TPDB24724

Antibacterial Anticancer Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB24724
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
standard
No
A 20-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
RFLKHLHTYYERAWHVIGHL
Physicochemical Analysis
C123H178N36O26
NDCQMPS
H
2576.99
10.08
7
1
10
+2
1.67
-0.455
97.50
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
8480
329.07
3
Residue Composition
number
1
A
2
R
0
N
0
D
0
C
1
E
0
Q
1
G
4
H
1
I
3
L
1
K
0
M
1
F
0
P
0
S
1
T
1
W
2
Y
1
V
Amino Acid Distribution
A: 1 R: 2 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 1 H: 4 I: 1 L: 3 K: 1 M: 0 F: 1 P: 0 S: 0 T: 1 W: 1 Y: 2 V: 1
Chemical Descriptors
20
C123H178N36O26
2576.99
10.08
+2
1.67
-0.455
Evidence Records 3 records
Evidence 1 Activity

Activity

EC50
Toxicity
2±2 µM
Cytotoxic
EC50 | 2±2 | µM | target cell: Human dermal microvascular endothelial cells HDME

Target

Human dermal microvascular endothelial cells HDME

Source & Reference

NA
DBAASP
In silico design and optimization of selective membranolytic anticancer peptides. | Sci Rep | 2019
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
>200 µM
Hemolytic Cytotoxic
50% Hemolysis | >200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
In silico design and optimization of selective membranolytic anticancer peptides. | Sci Rep | 2019
Evidence 3 Activity

Activity

HC50
Toxicity
200 µM
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: HC50>200 µM | Cytotoxicity: HDMEC: EC50=2 ± 2 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Sci Rep. 2019 Aug 2 9(1):11282.