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Peptide record

TPDB24716

Antibacterial Anticancer Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB24716
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
standard
No
A 20-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
RFLKHFKTVYKRYWKVLGRL
Physicochemical Analysis
C129H200N36O24
ANDCEQIMPS
K
2639.23
11.57
8
0
10
+7
-0.03
-0.575
87.50
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
8480
321.31
3
Residue Composition
number
0
A
3
R
0
N
0
D
0
C
0
E
0
Q
1
G
1
H
0
I
3
L
4
K
0
M
2
F
0
P
0
S
1
T
1
W
2
Y
2
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 0 L: 3 K: 4 M: 0 F: 2 P: 0 S: 0 T: 1 W: 1 Y: 2 V: 2
Chemical Descriptors
20
C129H200N36O24
2639.23
11.57
+7
-0.03
-0.575
Evidence Records 3 records
Evidence 1 Activity

Activity

EC50
Toxicity
14.3±0.2 µM
Cytotoxic
EC50 | 14.3±0.2 | µM | target cell: Human dermal microvascular endothelial cells HDME

Target

Human dermal microvascular endothelial cells HDME

Source & Reference

NA
DBAASP
In silico design and optimization of selective membranolytic anticancer peptides. | Sci Rep | 2019
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
144±4 µM
Hemolytic Cytotoxic
50% Hemolysis | 144±4 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
In silico design and optimization of selective membranolytic anticancer peptides. | Sci Rep | 2019
Evidence 3 Activity

Activity

HC50
Toxicity
144
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: HC50=144 ± 4 µM | Cytotoxicity: HDMEC: EC50=14.3 ± 0.2 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Sci Rep. 2019 Aug 2 9(1):11282.