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Peptide record

TPDB24711

Antibacterial Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB24711
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
standard
No
A 15-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
RFGRFLRKILRFLKK
Physicochemical Analysis
C95H160N30O16
ANDCEQHMPSTWYV
R
1978.51
12.88
7
0
7
+7
0.84
-0.387
104.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
4
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
1
I
3
L
3
K
0
M
3
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 3 K: 3 M: 0 F: 3 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
15
C95H160N30O16
1978.51
12.88
+7
0.84
-0.387
Evidence Records 6 records
Evidence 1 Activity

Activity

MIC
Antibacterial
32 µg/mL

Target

S. typhimurium NCTC 74

Source & Reference

NA

Other

active against Gram- E. coli O175:H7 (MIC 16 ug/ml), S. typhimurium NCTC 74 (MIC 32 ug/ml), and Gram+ S. aureus ATCC 9155 (MIC 16 ug/ml). Also active against B. subtilis (MIC 8-16
Evidence 2 Activity

Activity

MIC
Antibacterial
16 µg/mL

Target

Staphylococcus aureus ATCC 9155

Source & Reference

NA

Other

st Gram- E. coli O175:H7 (MIC 16 ug/ml), S. typhimurium NCTC 74 (MIC 32 ug/ml), and Gram+ S. aureus ATCC 9155 (MIC 16 ug/ml). Also active against B. subtilis (MIC 8-16 uM), P. aeruginosa (MIC 32-64 uM), MRSA 43300
Evidence 3 Activity

Activity

MIC
Antibacterial
8-16 µM

Target

B. subtilis

Source & Reference

NA

Other

NCTC 74 (MIC 32 ug/ml), and Gram+ S. aureus ATCC 9155 (MIC 16 ug/ml). Also active against B. subtilis (MIC 8-16 uM), P. aeruginosa (MIC 32-64 uM), MRSA 43300 or 13883 (MIC 32-64 uM).
Evidence 4 Activity

Activity

MIC
Antibacterial
32-64 µM

Target

Pseudomonas aeruginosa

Source & Reference

NA

Other

Gram+ S. aureus ATCC 9155 (MIC 16 ug/ml). Also active against B. subtilis (MIC 8-16 uM), P. aeruginosa (MIC 32-64 uM), MRSA 43300 or 13883 (MIC 32-64 uM).
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
216 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 216 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design, characterization and structure-function analysis of novel antimicrobial peptides based on the N-terminal CATH-2 fragment. | Sci Rep | 2022
Evidence 6 Activity

Activity

10% Cell death
Toxicity
1978.47 µg/mL
Cytotoxic
10% Cell death | 1978.47 | µg/mL | target cell: Murine macrophages

Target

Murine macrophages

Source & Reference

NA
DBAASP
Design, characterization and structure-function analysis of novel antimicrobial peptides based on the N-terminal CATH-2 fragment. | Sci Rep | 2022