TPDB

3D PDB MODEL

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TPDB ID TPDB24700

Activity

Antibacterial Antifungal

Activity_category_statistics

Anti-infective peptides

Database_Source

Peptipedia AFP-GFuse Antifungipept CAFPdb

Sequence_Type

standard

Has_Modification No

Description A 43-aa standard natural multi-activity (Antibacterial and Antifungal) peptide sequence curated from Peptipedia, AFP-GFuse, Antifungipept, and other sources, with an available 3D structural model.

Sequence

RFRPPILRPPIRPPFRPPFRPPVRPPIRPPFRPPFRPPIGPFP

FASTA

>TPDB24700|Antibacterial;Antifungal|length=43
RFRPPILRPPIRPPFRPPFRPPVRPPIRPPFRPPFRPPIGPFP

Formula C251H383N73O44

Absent Amino Acids ANDCEQHKMSTWY

Common Amino Acids P

Mass 5127.27

PI 13.35

Basic Residues 10

Acidic Residues 0

Hydrophobic Residues 12

Net Charge +10

Boman Index 8.60

Hydrophobicity -0.805

Aliphatic Index 52.09

Half Life

Mammalian: 1 hour Yeast: 2 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

0

A

10

R

0

N

0

D

0

C

0

E

0

Q

1

G

0

H

4

I

1

L

0

K

0

M

6

F

20

P

0

S

0

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 0 R: 10 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 4 L: 1 K: 0 M: 0 F: 6 P: 20 S: 0 T: 0 W: 0 Y: 0 V: 1

Length

43

Formula

C251H383N73O44

Mass

5127.27

PI

13.35

Net Charge

+10

Boman Index

8.60

Hydrophobicity

-0.805

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 10 µg/mL

Target

Target Organism Staphylococcus aureus 1056 MRSA

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli 0157:H7 (MIC 6 ug/ml), S. aureus 1056 MRSA (MIC 10 ug/ml), and C. albicans 3153A (MIC 45 ug/ml).

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 45 µg/mL

Target

Target Organism Candida albicans 3153A

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli 0157:H7 (MIC 6 ug/ml), S. aureus 1056 MRSA (MIC 10 ug/ml), and C. albicans 3153A (MIC 45 ug/ml).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 10 µg/mL

Target

Target Organism Staphylococcus aureus 1056 MRSA

Source & Reference

Database Source CAFPdb Antifungipept

Other

Evidence Text

Active against E. coli 0157:H7 (MIC 6 ug/ml), S. aureus 1056 MRSA (MIC 10 ug/ml), and C. albicans 3153A (MIC 45 ug/ml).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 45 µg/mL

Target

Target Organism Candida albicans 3153A

Source & Reference

Database Source CAFPdb Antifungipept

Other

Evidence Text

Active against E. coli 0157:H7 (MIC 6 ug/ml), S. aureus 1056 MRSA (MIC 10 ug/ml), and C. albicans 3153A (MIC 45 ug/ml).