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Peptide record

TPDB24697

Antibacterial Anticancer Toxicity standard
27 amino acids
Basic Information
3D PDB MODEL
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TPDB24697
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
standard
No
A 27-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
RFRLPFRRIHPPPFVRIHPPPFYRRFL
Physicochemical Analysis
C172H256N52O29
ANDCEQGKMSTW
RP
3516.26
12.80
9
0
11
+7
2.48
-0.578
68.52
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
1490
42.37
1
Residue Composition
number
0
A
7
R
0
N
0
D
0
C
0
E
0
Q
0
G
2
H
2
I
2
L
0
K
0
M
5
F
7
P
0
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 7 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 2 I: 2 L: 2 K: 0 M: 0 F: 5 P: 7 S: 0 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
27
C172H256N52O29
3516.26
12.80
+7
2.48
-0.578
Evidence Records 5 records
Evidence 1 Activity

Activity

50% Cytotoxicity
Toxicity
12.1±0.8 µM
Cytotoxic
50% Cytotoxicity | 12.1±0.8 | µM | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Caprine Bactenecins as Promising Tools for Developing New Antimicrobial and Antitumor Drugs. | Front Cell Infect Microbiol | 2020
Evidence 2 Activity

Activity

<5% Hemolysis
Toxicity
64 µM
Hemolytic Cytotoxic
<5% Hemolysis | 64 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Caprine Bactenecins as Promising Tools for Developing New Antimicrobial and Antitumor Drugs. | Front Cell Infect Microbiol | 2020
Evidence 3 Activity

Activity

50% Cytotoxicity
Toxicity
33.7±3.2 µM
Cytotoxic
50% Cytotoxicity | 33.7±3.2 | µM | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Caprine Bactenecins as Promising Tools for Developing New Antimicrobial and Antitumor Drugs. | Front Cell Infect Microbiol | 2020
Evidence 4 Activity

Activity

IC50
Toxicity
12.1
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: <5% Hemolysis=64 µM | Cytotoxicity: Human PBMC: IC50=12.1 ± 0.8 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Front Cell Infect Microbiol. 2020 Oct 19 10:552905.
Evidence 5 Activity

Activity

IC50
Toxicity
33.7
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: <5% Hemolysis=64 µM | Cytotoxicity: Human PBMC: IC50=33.7 ± 3.2 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Front Cell Infect Microbiol. 2020 Oct 19 10:552905.