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Peptide record

TPDB24688

Antibacterial Anticancer Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB24688
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
standard
No
A 23-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
RAVIYKIPYNAIASRWIIAPKKC
Physicochemical Analysis
C126H204N34O28S1
DEQGHLMFT
I
2675.28
10.55
5
0
13
+5
-0.09
0.204
114.78
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
8480
316.98
5
Residue Composition
number
4
A
2
R
1
N
0
D
1
C
0
E
0
Q
0
G
0
H
5
I
0
L
3
K
0
M
0
F
2
P
1
S
0
T
1
W
2
Y
1
V
Amino Acid Distribution
A: 4 R: 2 N: 1 D: 0 C: 1 E: 0 Q: 0 G: 0 H: 0 I: 5 L: 0 K: 3 M: 0 F: 0 P: 2 S: 1 T: 0 W: 1 Y: 2 V: 1
Chemical Descriptors
23
C126H204N34O28S1
2675.28
10.55
+5
-0.09
0.204
Evidence Records 12 records
Evidence 1 Activity

Activity

MIC
Antibacterial
12 µM

Target

B. subtilis 168HT

Source & Reference

NA

Other

Active against Gram+ B. subtilis 168HT (MIC 12 uM), S.aureus ST 88 (MIC >100 uM), S. hemolyticus 527 (MIC 47.8 uM), M. smegmatis (MIC 47.8 u
Evidence 2 Activity

Activity

MIC
Antibacterial
>100 µM

Target

S.aureus ST 88

Source & Reference

NA

Other

Active against Gram+ B. subtilis 168HT (MIC 12 uM), S.aureus ST 88 (MIC >100 uM), S. hemolyticus 527 (MIC 47.8 uM), M. smegmatis (MIC 47.8 uM), Gram- E. coli MG1655 (MIC
Evidence 3 Activity

Activity

MIC
Antibacterial
47.8 µM

Target

S. hemolyticus 527

Source & Reference

NA

Other

Active against Gram+ B. subtilis 168HT (MIC 12 uM), S.aureus ST 88 (MIC >100 uM), S. hemolyticus 527 (MIC 47.8 uM), M. smegmatis (MIC 47.8 uM), Gram- E. coli MG1655 (MIC 23.9 uM), K.pneumonia 148 (MIC >10
Evidence 4 Activity

Activity

MIC
Antibacterial
47.8 µM

Target

M. smegmatis

Source & Reference

NA

Other

btilis 168HT (MIC 12 uM), S.aureus ST 88 (MIC >100 uM), S. hemolyticus 527 (MIC 47.8 uM), M. smegmatis (MIC 47.8 uM), Gram- E. coli MG1655 (MIC 23.9 uM), K.pneumonia 148 (MIC >100 uM), K.pneumonia 50 (MIC >
Evidence 5 Activity

Activity

MIC
Antibacterial
23.9 µM

Target

Escherichia coli MG1655

Source & Reference

NA

Other

ST 88 (MIC >100 uM), S. hemolyticus 527 (MIC 47.8 uM), M. smegmatis (MIC 47.8 uM), Gram- E. coli MG1655 (MIC 23.9 uM), K.pneumonia 148 (MIC >100 uM), K.pneumonia 50 (MIC >100 uM), K.pneumonia ’18-3 (MIC >100
Evidence 6 Activity

Activity

MIC
Antibacterial
>100 µM

Target

K.pneumonia 148

Source & Reference

NA

Other

yticus 527 (MIC 47.8 uM), M. smegmatis (MIC 47.8 uM), Gram- E. coli MG1655 (MIC 23.9 uM), K.pneumonia 148 (MIC >100 uM), K.pneumonia 50 (MIC >100 uM), K.pneumonia ’18-3 (MIC >100 uM), K.pneumonia 231 (MIC >100
Evidence 7 Activity

Activity

MIC
Antibacterial
>100 µM

Target

K.pneumonia 50

Source & Reference

NA

Other

egmatis (MIC 47.8 uM), Gram- E. coli MG1655 (MIC 23.9 uM), K.pneumonia 148 (MIC >100 uM), K.pneumonia 50 (MIC >100 uM), K.pneumonia ’18-3 (MIC >100 uM), K.pneumonia 231 (MIC >100 uM).
Evidence 8 Activity

Activity

MIC
Antibacterial
>100 µM

Target

K.pneumonia 231

Source & Reference

NA

Other

eumonia 148 (MIC >100 uM), K.pneumonia 50 (MIC >100 uM), K.pneumonia ’18-3 (MIC >100 uM), K.pneumonia 231 (MIC >100 uM).
Evidence 9 Activity

Activity

50% Hemolysis
Toxicity
>200 µM
Hemolytic Cytotoxic
50% Hemolysis | >200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Non-toxic antimicrobial peptide Hm-AMP2 from leech metagenome | Mater Des | 2022
Evidence 10 Activity

Activity

LC90
Toxicity
>100 µM
Cytotoxic
LC90 | >100 | µM | target cell: Mouse fibroblasts McCoy

Target

Mouse fibroblasts McCoy

Source & Reference

NA
DBAASP
Non-toxic antimicrobial peptide Hm-AMP2 from leech metagenome | Mater Des | 2022
Evidence 11 Activity

Activity

LC90
Toxicity
100 µM
Cytotoxic
LC90 | 100 | µM | target cell: Human primary fibroblasts FF1

Target

Human primary fibroblasts FF1

Source & Reference

NA
DBAASP
Non-toxic antimicrobial peptide Hm-AMP2 from leech metagenome | Mater Des | 2022
Evidence 12 Activity

Activity

LC90
Toxicity
100 µM
Cytotoxic
LC90 | 100 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Non-toxic antimicrobial peptide Hm-AMP2 from leech metagenome | Mater Des | 2022