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Peptide record

TPDB24583

Antibacterial Antifungal Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB24583
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia AFP-GFuse
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from Peptipedia and AFP-GFuse, with an available 3D structural model.
Sequence
RALRKALKAWRKLAKKLQ
Physicochemical Analysis
C100H180N34O20
NDCEGHIMFPSTYV
K
2178.74
12.72
8
0
9
+8
3.19
-0.833
108.89
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
5500
252.44
1
Residue Composition
number
4
A
3
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
0
I
4
L
5
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 4 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 4 K: 5 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
18
C100H180N34O20
2178.74
12.72
+8
3.19
-0.833
Evidence Records 18 records
Evidence 1 Activity

Activity

MIC
Antibacterial
5 µM

Target

C. gattii AFLP4

Source & Reference

NA

Other

active against C. gattii AFLP4 (MIC 5 uM), C. guilliermondii ATCC 6260 (MIC 2.5 uM), C. tropicalis ATCC 750 (MIC 5 uM), C. utilis A
Evidence 2 Activity

Activity

MIC
Antibacterial
2.5 µM

Target

C. guilliermondii ATCC 6260

Source & Reference

NA

Other

active against C. gattii AFLP4 (MIC 5 uM), C. guilliermondii ATCC 6260 (MIC 2.5 uM), C. tropicalis ATCC 750 (MIC 5 uM), C. utilis ATCC 9950 (MIC 5 uM), (MIC 2.5 uM), C. para
Evidence 3 Activity

Activity

MIC
Antibacterial
5 µM

Target

C. tropicalis ATCC 750

Source & Reference

NA

Other

active against C. gattii AFLP4 (MIC 5 uM), C. guilliermondii ATCC 6260 (MIC 2.5 uM), C. tropicalis ATCC 750 (MIC 5 uM), C. utilis ATCC 9950 (MIC 5 uM), (MIC 2.5 uM), C. parapsilosis ATCC 2209 (MIC 10 uM), C.
Evidence 4 Activity

Activity

MIC
Antibacterial
5 µM

Target

C. utilis ATCC 9950

Source & Reference

NA

Other

(MIC 5 uM), C. guilliermondii ATCC 6260 (MIC 2.5 uM), C. tropicalis ATCC 750 (MIC 5 uM), C. utilis ATCC 9950 (MIC 5 uM), (MIC 2.5 uM), C. parapsilosis ATCC 2209 (MIC 10 uM), C. albicans MYA 2876 (MIC 2.5 uM),
Evidence 5 Activity

Activity

MIC
Antibacterial
10 µM

Target

C. parapsilosis ATCC 2209

Source & Reference

NA

Other

2.5 uM), C. tropicalis ATCC 750 (MIC 5 uM), C. utilis ATCC 9950 (MIC 5 uM), (MIC 2.5 uM), C. parapsilosis ATCC 2209 (MIC 10 uM), C. albicans MYA 2876 (MIC 2.5 uM), C. krusei ATCC 6258 (MIC 30 uM), and C-glabrata ATCC
Evidence 6 Activity

Activity

MIC
Antibacterial
2.5 µM

Target

Candida albicans MYA 2876

Source & Reference

NA

Other

uM), C. utilis ATCC 9950 (MIC 5 uM), (MIC 2.5 uM), C. parapsilosis ATCC 2209 (MIC 10 uM), C. albicans MYA 2876 (MIC 2.5 uM), C. krusei ATCC 6258 (MIC 30 uM), and C-glabrata ATCC 1707 or ATCC 90030 (MIC>40 uM). Fun
Evidence 7 Activity

Activity

MIC
Antibacterial
30 µM

Target

C. krusei ATCC 6258

Source & Reference

NA

Other

, (MIC 2.5 uM), C. parapsilosis ATCC 2209 (MIC 10 uM), C. albicans MYA 2876 (MIC 2.5 uM), C. krusei ATCC 6258 (MIC 30 uM), and C-glabrata ATCC 1707 or ATCC 90030 (MIC>40 uM). Fungicidal concentrations are simila
Evidence 8 Activity

Activity

MIC
Antifungal
5 µM

Target

C. gattii AFLP4

Source & Reference

NA

Other

active against C. gattii AFLP4 (MIC 5 uM), C. guilliermondii ATCC 6260 (MIC 2.5 uM), C. tropicalis ATCC 750 (MIC 5 uM), C. utilis A
Evidence 9 Activity

Activity

MIC
Antifungal
2.5 µM

Target

C. guilliermondii ATCC 6260

Source & Reference

NA

Other

active against C. gattii AFLP4 (MIC 5 uM), C. guilliermondii ATCC 6260 (MIC 2.5 uM), C. tropicalis ATCC 750 (MIC 5 uM), C. utilis ATCC 9950 (MIC 5 uM), (MIC 2.5 uM), C. para
Evidence 10 Activity

Activity

MIC
Antifungal
5 µM

Target

C. tropicalis ATCC 750

Source & Reference

NA

Other

active against C. gattii AFLP4 (MIC 5 uM), C. guilliermondii ATCC 6260 (MIC 2.5 uM), C. tropicalis ATCC 750 (MIC 5 uM), C. utilis ATCC 9950 (MIC 5 uM), (MIC 2.5 uM), C. parapsilosis ATCC 2209 (MIC 10 uM), C.
Evidence 11 Activity

Activity

MIC
Antifungal
5 µM

Target

C. utilis ATCC 9950

Source & Reference

NA

Other

(MIC 5 uM), C. guilliermondii ATCC 6260 (MIC 2.5 uM), C. tropicalis ATCC 750 (MIC 5 uM), C. utilis ATCC 9950 (MIC 5 uM), (MIC 2.5 uM), C. parapsilosis ATCC 2209 (MIC 10 uM), C. albicans MYA 2876 (MIC 2.5 uM),
Evidence 12 Activity

Activity

MIC
Antifungal
10 µM

Target

C. parapsilosis ATCC 2209

Source & Reference

NA

Other

2.5 uM), C. tropicalis ATCC 750 (MIC 5 uM), C. utilis ATCC 9950 (MIC 5 uM), (MIC 2.5 uM), C. parapsilosis ATCC 2209 (MIC 10 uM), C. albicans MYA 2876 (MIC 2.5 uM), C. krusei ATCC 6258 (MIC 30 uM), and C-glabrata ATCC
Evidence 13 Activity

Activity

MIC
Antifungal
2.5 µM

Target

Candida albicans MYA 2876

Source & Reference

NA

Other

uM), C. utilis ATCC 9950 (MIC 5 uM), (MIC 2.5 uM), C. parapsilosis ATCC 2209 (MIC 10 uM), C. albicans MYA 2876 (MIC 2.5 uM), C. krusei ATCC 6258 (MIC 30 uM), and C-glabrata ATCC 1707 or ATCC 90030 (MIC>40 uM). Fun
Evidence 14 Activity

Activity

MIC
Antifungal
30 µM

Target

C. krusei ATCC 6258

Source & Reference

NA

Other

, (MIC 2.5 uM), C. parapsilosis ATCC 2209 (MIC 10 uM), C. albicans MYA 2876 (MIC 2.5 uM), C. krusei ATCC 6258 (MIC 30 uM), and C-glabrata ATCC 1707 or ATCC 90030 (MIC>40 uM). Fungicidal concentrations are simila
Evidence 15 Activity

Activity

IC50
Toxicity
57.4±4.3 µM
Cytotoxic
IC50 | 57.4±4.3 | µM | target cell: Human fibroblasts MRC-5

Target

Human fibroblasts MRC-5

Source & Reference

NA
DBAASP
Differential interactions of the antimicrobial peptide, RQ18, with phospholipids and cholesterol modulate its selectivity for microorganism membranes. | Biochim Biophys Acta | 2021
Evidence 16 Activity

Activity

IC50
Toxicity
88.0±7.1 µM
Cytotoxic
IC50 | 88.0±7.1 | µM | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Differential interactions of the antimicrobial peptide, RQ18, with phospholipids and cholesterol modulate its selectivity for microorganism membranes. | Biochim Biophys Acta | 2021
Evidence 17 Activity

Activity

IC50
Toxicity
97.4±8.7 µM
Cytotoxic
IC50 | 97.4±8.7 | µM | target cell: Vero cells

Target

Vero cells

Source & Reference

NA
DBAASP
Differential interactions of the antimicrobial peptide, RQ18, with phospholipids and cholesterol modulate its selectivity for microorganism membranes. | Biochim Biophys Acta | 2021
Evidence 18 Activity

Activity

50% Hemolysis
Toxicity
>300 µM
Hemolytic Cytotoxic
50% Hemolysis | >300 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Differential interactions of the antimicrobial peptide, RQ18, with phospholipids and cholesterol modulate its selectivity for microorganism membranes. | Biochim Biophys Acta | 2021