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Peptide record

TPDB24573

BR2 Antibacterial Anticancer Cell-penetrating Peptides Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB24573
BR2
Antibacterial Anticancer Cell-penetrating Peptides Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
Peptipedia CPPsite3.0
standard
No
A 17-aa standard natural multi-activity (Antibacterial, Anticancer, Cell-penetrating Peptides, and other sources) peptide sequence curated from Peptipedia and CPPsite3.0, with an available 3D structural model.
Sequence
RAGLQFPVGRLLRRLLR
Physicochemical Analysis
C91H161N33O19
NDCEHIKMSTWY
RL
2021.49
13.00
5
0
8
+5
1.07
-0.035
137.65
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
1
Residue Composition
number
1
A
5
R
0
N
0
D
0
C
0
E
1
Q
2
G
0
H
0
I
5
L
0
K
0
M
1
F
1
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 5 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 2 H: 0 I: 0 L: 5 K: 0 M: 0 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
17
C91H161N33O19
2021.49
13.00
+5
1.07
-0.035
Free
L
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 5 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Fn1, MDA-MB-231 , 4T1 And HUVEC Cell Lines

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
2-aminoethyl dihydrogen phosphate (2-AEH2P)
In vitro
CCGGGTSCC
Evidence 2 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A cancer specific cell-penetrating peptide, BR2, for the efficient delivery of an scFv into cancer cells. | PLoS One | 2013
Evidence 3 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
A cancer specific cell-penetrating peptide, BR2, for the efficient delivery of an scFv into cancer cells. | PLoS One | 2013
Evidence 4 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human fibroblasts

Target

Human fibroblasts

Source & Reference

NA
DBAASP
A cancer specific cell-penetrating peptide, BR2, for the efficient delivery of an scFv into cancer cells. | PLoS One | 2013
Evidence 5 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
PLoS One. 2013 Jun 11 8(6):e66084.
Additional Detail Fields 1 fields
CCGGGTSCC