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Peptide record

TPDB24570

Antibacterial Anticancer Hemolysis Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB24570
Antibacterial Anticancer Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia PD_Hemolysis
standard
No
A 20-aa standard natural multi-activity (Antibacterial, Anticancer, Hemolysis, and other sources) peptide sequence curated from Peptipedia and PD_Hemolysis, with an available 3D structural model.
Sequence
QYLRRVRTWLRRAWHILGKV
Physicochemical Analysis
C121H195N41O24
NDCEMFPS
R
2608.14
12.58
7
0
10
+6
0.07
-0.560
112.00
Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour
12490
478.89
3
Residue Composition
number
1
A
5
R
0
N
0
D
0
C
0
E
1
Q
1
G
1
H
1
I
3
L
1
K
0
M
0
F
0
P
0
S
1
T
2
W
1
Y
2
V
Amino Acid Distribution
A: 1 R: 5 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 1 I: 1 L: 3 K: 1 M: 0 F: 0 P: 0 S: 0 T: 1 W: 2 Y: 1 V: 2
Chemical Descriptors
20
C121H195N41O24
2608.14
12.58
+6
0.07
-0.560
Evidence Records 5 records
Evidence 1 Activity

Activity

HC50
Hemolysis
21
Human erythrocytes: HC50=21 ± 1 µM

Target

Human erythrocytes

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
Sci Rep. 2019 Aug 2 9(1):11282.

Other

Source Activity Label Source Definition
Hemolysis
Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

EC50
Toxicity
10.3±0.3 µM
Cytotoxic
EC50 | 10.3±0.3 | µM | target cell: Human dermal microvascular endothelial cells HDME

Target

Human dermal microvascular endothelial cells HDME

Source & Reference

NA
DBAASP
In silico design and optimization of selective membranolytic anticancer peptides. | Sci Rep | 2019
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
21±1 µM
Hemolytic Cytotoxic
50% Hemolysis | 21±1 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
In silico design and optimization of selective membranolytic anticancer peptides. | Sci Rep | 2019
Evidence 4 Activity

Activity

HC50
Toxicity
21
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: HC50=21 ± 1 µM | Cytotoxicity: HDMEC: EC50=10.3 ± 0.3 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Sci Rep. 2019 Aug 2 9(1):11282.
Evidence 5 Hemolysis

Activity

21
HC50
Human erythrocytes: HC50=21 ± 1 µM
Hemolysis

Target

Human erythrocytes

Source & Reference

PD_Hemolysis
Sci Rep. 2019 Aug 2 9(1):11282.
DRAMP4
PD_Hemolysis