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Peptide record

TPDB24559

Antibacterial Anticancer Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB24559
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
standard
No
A 20-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
QVFKKFRPFYRRPWELFGKL
Physicochemical Analysis
C131H192N34O25
ANDCHIMST
F
2643.18
11.49
6
1
9
+5
0.55
-0.750
53.50
Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour
6990
264.45
2
Residue Composition
number
0
A
3
R
0
N
0
D
0
C
1
E
1
Q
1
G
0
H
0
I
2
L
3
K
0
M
4
F
2
P
0
S
0
T
1
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 0 E: 1 Q: 1 G: 1 H: 0 I: 0 L: 2 K: 3 M: 0 F: 4 P: 2 S: 0 T: 0 W: 1 Y: 1 V: 1
Chemical Descriptors
20
C131H192N34O25
2643.18
11.49
+5
0.55
-0.750
Evidence Records 3 records
Evidence 1 Activity

Activity

EC50
Toxicity
173±1 µM
Cytotoxic
EC50 | 173±1 | µM | target cell: Human dermal microvascular endothelial cells HDME

Target

Human dermal microvascular endothelial cells HDME

Source & Reference

NA
DBAASP
In silico design and optimization of selective membranolytic anticancer peptides. | Sci Rep | 2019
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
>200 µM
Hemolytic Cytotoxic
50% Hemolysis | >200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
In silico design and optimization of selective membranolytic anticancer peptides. | Sci Rep | 2019
Evidence 3 Activity

Activity

HC50
Toxicity
200 µM
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: HC50>200 µM | Cytotoxicity: HDMEC: EC50=173 ± 1 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Sci Rep. 2019 Aug 2 9(1):11282.