TPDB

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB24554

Activity

Antibacterial Antifungal Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

Peptipedia Antifungipept

Sequence_Type

standard

Has_Modification No

Description A 97-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from Peptipedia and Antifungipept, with an available 3D structural model.

Sequence

QYEALVASILGKLSGLWHSDTVDFMGHTCHIRRRPKFRKFKLYHEGKFWCPGWTHLEGNSRTKSRSGSARDAIKDFVYKALQNKLITENNAAAWLKG

FASTA

>TPDB24554|Antibacterial;Antifungal;Toxicity|length=97
QYEALVASILGKLSGLWHSDTVDFMGHTCHIRRRPKFRKFKLYHEGKFWCPGWTHLEGNSRTKSRSGSARDAIKDFVYKALQNKLITENNAAAWLKG

Formula C505H778N148O135S3

Absent Amino Acids

Common Amino Acids K

Mass 11178.82

PI 10.35

Basic Residues 22

Acidic Residues 8

Hydrophobic Residues 37

Net Charge +9

Boman Index 14.79

Hydrophobicity -0.602

Aliphatic Index 69.48

Half Life

Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour

Extinction Coefficient Cystines 26595

Absorbance 280nm 237.91

Polar Residues 23

number

8

A

7

R

4

N

4

D

2

C

4

E

2

Q

8

G

5

H

4

I

9

L

10

K

1

M

5

F

2

P

7

S

5

T

4

W

3

Y

3

V

Amino Acid Distribution

A: 8 R: 7 N: 4 D: 4 C: 2 E: 4 Q: 2 G: 8 H: 5 I: 4 L: 9 K: 10 M: 1 F: 5 P: 2 S: 7 T: 5 W: 4 Y: 3 V: 3

Length

97

Formula

C505H778N148O135S3

Mass

11178.82

PI

10.35

Net Charge

+9

Boman Index

14.79

Hydrophobicity

-0.602

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 50-100 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source NA

Other

Evidence Text

recombinant SsALF (rSsALF) showed some activity against Gram- E. coli (MIC 50-100 ug/ml), P. aeruginosa (MIC 25-50 ug/ml), Gram+ S.aureus (MIC > 200 ug/ml), and S.pyogenes (MIC 1

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 25-50 µg/mL

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source NA

Other

Evidence Text

recombinant SsALF (rSsALF) showed some activity against Gram- E. coli (MIC 50-100 ug/ml), P. aeruginosa (MIC 25-50 ug/ml), Gram+ S.aureus (MIC > 200 ug/ml), and S.pyogenes (MIC 100-200 ug/ml).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 100-200 µg/mL

Target

Target Organism S.pyogenes

Source & Reference

Database Source NA

Other

Evidence Text

MIC 50-100 ug/ml), P. aeruginosa (MIC 25-50 ug/ml), Gram+ S.aureus (MIC > 200 ug/ml), and S.pyogenes (MIC 100-200 ug/ml).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 50-100 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source Antifungipept

Other

Evidence Text

recombinant SsALF (rSsALF) showed some activity against Gram- E. coli (MIC 50-100 ug/ml), P. aeruginosa (MIC 25-50 ug/ml), Gram+ S.aureus (MIC > 200 ug/ml), and S.pyogenes (MIC 1

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 25-50 µg/mL

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source Antifungipept

Other

Evidence Text

recombinant SsALF (rSsALF) showed some activity against Gram- E. coli (MIC 50-100 ug/ml), P. aeruginosa (MIC 25-50 ug/ml), Gram+ S.aureus (MIC > 200 ug/ml), and S.pyogenes (MIC 100-200 ug/ml).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 100-200 µg/mL

Target

Target Organism S.pyogenes

Source & Reference

Database Source Antifungipept

Other

Evidence Text

MIC 50-100 ug/ml), P. aeruginosa (MIC 25-50 ug/ml), Gram+ S.aureus (MIC > 200 ug/ml), and S.pyogenes (MIC 100-200 ug/ml).