TPDB

3D PDB MODEL

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TPDB ID TPDB24535

Peptide_Name

Apelin-13

Activity

Antibacterial Antiviral Neuropeptide

Activity_category_statistics

Anti-infective peptides Neuroactive peptides

Database_Source

Peptipedia AI4AVP dbAMP 3.0 DRAVP 2.0

Sequence_Type

standard

Has_Modification No

Description A 13-aa standard natural multi-activity (Antibacterial, Antiviral, and Neuropeptide) peptide sequence curated from Peptipedia, AI4AVP, dbAMP 3.0, and other sources, with an available 3D structural model.

Sequence

QRPRLSHKGPMPF

FASTA

>TPDB24535|Antibacterial;Antiviral;Neuropeptide|length=13
QRPRLSHKGPMPF

Formula C69H111N23O16S1

Absent Amino Acids ANDCEITWYV

Common Amino Acids P

Mass 1550.85

PI 12.41

Basic Residues 4

Acidic Residues 0

Hydrophobic Residues 3

Net Charge +3

Boman Index 3.72

Hydrophobicity -1.315

Aliphatic Index 30.00

Half Life

Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 2

number

0

A

2

R

0

N

0

D

0

C

0

E

1

Q

1

G

1

H

0

I

1

L

1

K

1

M

1

F

3

P

1

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 1 I: 0 L: 1 K: 1 M: 1 F: 1 P: 3 S: 1 T: 0 W: 0 Y: 0 V: 0

Length

13

Formula

C69H111N23O16S1

Mass

1550.85

PI

12.41

Net Charge

+3

Boman Index

3.72

Hydrophobicity

-1.315

Evidence 1 Activity

Activity

Detail Source Activity Antibacterial

Source & Reference

Database Source NA

Other

Evidence Text

inhibit HIV-1 infection (IC50 26 ug/ml).

Evidence 2 Activity

Activity

Detail Source Activity Antiviral

Source & Reference

Database Source dbAMP 3.0 DRAVP 2.0

Other

Source Activity Label	Source Definition
Antiviral	dbAMP 3.0 classified under the Anti-viral function class.

Evidence Text

inhibit HIV-1 infection (IC50 26 ug/ml).

Evidence 3 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Bos taurus

Family Apelin

Evidence 4 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Apelin receptor

Receptor Organisms Homo sapiens

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Homo sapiens

Family Apelin

Receptor Lengths 380

Receptor Ligands NP01228 NP01232 NP01236 NP01240

Evidence 5 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Apelin receptor

Receptor Organisms Mus musculus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Mus musculus

Family Apelin

Receptor Lengths 377

Receptor Ligands NP01229 NP01233 NP01237 NP01241

Evidence 6 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Apelin receptor

Receptor Organisms Rattus norvegicus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Rattus norvegicus

Family Apelin

Receptor Lengths 377

Receptor Ligands NP01230 NP01234 NP01238 NP01242

Family

Apelin

Receptor_Lengths

380 377

Receptor_Ligands

NP01228 NP01232 NP01236 NP01240 NP01229 NP01233 NP01237 NP01241 NP01230 NP01234 NP01238 NP01242