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Peptide record

TPDB24523

Antibacterial Anticancer Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB24523
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
standard
No
A 20-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
QRIRQLHTWIKKAWHIWPKI
Physicochemical Analysis
C127H196N38O24
NDCEGMFSYV
I
2639.19
12.43
7
0
9
+5
0.74
-0.775
102.50
Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour
16500
625.19
3
Residue Composition
number
1
A
2
R
0
N
0
D
0
C
0
E
2
Q
0
G
2
H
4
I
1
L
3
K
0
M
0
F
1
P
0
S
1
T
3
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 2 I: 4 L: 1 K: 3 M: 0 F: 0 P: 1 S: 0 T: 1 W: 3 Y: 0 V: 0
Chemical Descriptors
20
C127H196N38O24
2639.19
12.43
+5
0.74
-0.775
Evidence Records 3 records
Evidence 1 Activity

Activity

EC50
Toxicity
39.7±0.3 µM
Cytotoxic
EC50 | 39.7±0.3 | µM | target cell: Human dermal microvascular endothelial cells HDME

Target

Human dermal microvascular endothelial cells HDME

Source & Reference

NA
DBAASP
In silico design and optimization of selective membranolytic anticancer peptides. | Sci Rep | 2019
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
>200 µM
Hemolytic Cytotoxic
50% Hemolysis | >200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
In silico design and optimization of selective membranolytic anticancer peptides. | Sci Rep | 2019
Evidence 3 Activity

Activity

HC50
Toxicity
200 µM
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: HC50>200 µM | Cytotoxicity: HDMEC: EC50=39.7 ± 0.3 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Sci Rep. 2019 Aug 2 9(1):11282.