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Peptide record

TPDB24451

Antibacterial Anticancer Antifungal Antiparasitic standard

51 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB24451

Activity

Antibacterial Anticancer Antifungal Antiparasitic

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

Peptipedia Antifungipept CAFPdb DRAMP dbAMP

Sequence_Type

standard

Has_Modification No

Description A 51-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, Antifungipept, CAFPdb, and other sources, with an available 3D structural model.

Sequence

QKLCERPSGTWSGVCGNNNACKNQCINLEKARHGSCNYVFPAHKCICYFPC

FASTA

>TPDB24451|Antibacterial;Anticancer;Antifungal;Antiparasitic|length=51
QKLCERPSGTWSGVCGNNNACKNQCINLEKARHGSCNYVFPAHKCICYFPC

Formula C242H372N74O70S8

Absent Amino Acids DM

Common Amino Acids C

Mass 5694.55

PI 8.31

Basic Residues 8

Acidic Residues 2

Hydrophobic Residues 14

Net Charge +4

Boman Index 7.12

Hydrophobicity -0.451

Aliphatic Index 47.84

Half Life

Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour

Extinction Coefficient Cystines 8980

Absorbance 280nm 157.69

Polar Residues 22

number

Amino Acid Distribution

A: 3 R: 2 N: 6 D: 0 C: 8 E: 2 Q: 2 G: 4 H: 2 I: 2 L: 2 K: 4 M: 0 F: 2 P: 3 S: 3 T: 1 W: 1 Y: 2 V: 2

Length

Formula

C242H372N74O70S8

Mass

5694.55

8.31

Net Charge

Boman Index

7.12

Hydrophobicity

-0.451

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 15 µg/mL

Target

Target Organism A. brassicola

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	DRAMP antibacterial activity supported by MIC records against bacterial target organisms. dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

low salt medium A: active against A. brassicola (IC50 15 ug/ml), B. cinerea (IC50 8 ug/ml), F. culmorum (IC50 5 ug/ml), F. oxysporum f.sp. lycopersici (I

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 8 µg/mL

Target

Target Organism B. cinerea

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

low salt medium A: active against A. brassicola (IC50 15 ug/ml), B. cinerea (IC50 8 ug/ml), F. culmorum (IC50 5 ug/ml), F. oxysporum f.sp. lycopersici (IC50 30 ug/ml), P. oryzae (I

Evidence 3 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 5 µg/mL

Target

Target Organism F. culmorum

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

w salt medium A: active against A. brassicola (IC50 15 ug/ml), B. cinerea (IC50 8 ug/ml), F. culmorum (IC50 5 ug/ml), F. oxysporum f.sp. lycopersici (IC50 30 ug/ml), P. oryzae (IC50 0.3 ug/ml), and V. dahli

Evidence 4 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 30 µg/mL

Target

Target Organism p. lycopersici

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

a (IC50 15 ug/ml), B. cinerea (IC50 8 ug/ml), F. culmorum (IC50 5 ug/ml), F. oxysporum f.sp. lycopersici (IC50 30 ug/ml), P. oryzae (IC50 0.3 ug/ml), and V. dahliae (IC50 5 ug/ml). Active against fungi A. brass

Evidence 5 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 0.3 µg/mL

Target

Target Organism P. oryzae

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

C50 8 ug/ml), F. culmorum (IC50 5 ug/ml), F. oxysporum f.sp. lycopersici (IC50 30 ug/ml), P. oryzae (IC50 0.3 ug/ml), and V. dahliae (IC50 5 ug/ml). Active against fungi A. brassicola (IC50 15 ug/ml), B. ci

Evidence 6 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 5 µg/mL

Target

Target Organism V. dahliae

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

5 ug/ml), F. oxysporum f.sp. lycopersici (IC50 30 ug/ml), P. oryzae (IC50 0.3 ug/ml), and V. dahliae (IC50 5 ug/ml). Active against fungi A. brassicola (IC50 15 ug/ml), B. cinerea (IC50 8 ug/ml), and F. cu

Evidence 7 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 15 µg/mL

Target

Target Organism A. brassicola

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

0 ug/ml), P. oryzae (IC50 0.3 ug/ml), and V. dahliae (IC50 5 ug/ml). Active against fungi A. brassicola (IC50 15 ug/ml), B. cinerea (IC50 8 ug/ml), and F. culmorum (IC50 5 ug/ml).

Evidence 8 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 8 µg/mL

Target

Target Organism B. cinerea

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

g/ml), and V. dahliae (IC50 5 ug/ml). Active against fungi A. brassicola (IC50 15 ug/ml), B. cinerea (IC50 8 ug/ml), and F. culmorum (IC50 5 ug/ml).

Evidence 9 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 5 µg/mL

Target

Target Organism F. culmorum

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

g/ml). Active against fungi A. brassicola (IC50 15 ug/ml), B. cinerea (IC50 8 ug/ml), and F. culmorum (IC50 5 ug/ml).

Evidence 10 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 15 µg/mL

Target

Target Organism A. brassicola

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	DRAMP antifungal activity supported by activity records against fungal target organisms. dbAMP classified under the Anti-fungal function class.

Evidence Text

low salt medium A: active against A. brassicola (IC50 15 ug/ml), B. cinerea (IC50 8 ug/ml), F. culmorum (IC50 5 ug/ml), F. oxysporum f.sp. lycopersici (I

Evidence 11 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 8 µg/mL

Target

Target Organism B. cinerea

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

low salt medium A: active against A. brassicola (IC50 15 ug/ml), B. cinerea (IC50 8 ug/ml), F. culmorum (IC50 5 ug/ml), F. oxysporum f.sp. lycopersici (IC50 30 ug/ml), P. oryzae (I

Evidence 12 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 5 µg/mL

Target

Target Organism F. culmorum

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 13 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 30 µg/mL

Target

Target Organism p. lycopersici

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 14 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 0.3 µg/mL

Target

Target Organism P. oryzae

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 15 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 5 µg/mL

Target

Target Organism V. dahliae

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 16 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 15 µg/mL

Target

Target Organism A. brassicola

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

0 ug/ml), P. oryzae (IC50 0.3 ug/ml), and V. dahliae (IC50 5 ug/ml). Active against fungi A. brassicola (IC50 15 ug/ml), B. cinerea (IC50 8 ug/ml), and F. culmorum (IC50 5 ug/ml).

Evidence 17 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 8 µg/mL

Target

Target Organism B. cinerea

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

g/ml), and V. dahliae (IC50 5 ug/ml). Active against fungi A. brassicola (IC50 15 ug/ml), B. cinerea (IC50 8 ug/ml), and F. culmorum (IC50 5 ug/ml).

Evidence 18 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 5 µg/mL

Target

Target Organism F. culmorum

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

g/ml). Active against fungi A. brassicola (IC50 15 ug/ml), B. cinerea (IC50 8 ug/ml), and F. culmorum (IC50 5 ug/ml).

Evidence 19 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 15 µg/mL

Target

Target Organism A. brassicola

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

low salt medium A: active against A. brassicola (IC50 15 ug/ml), B. cinerea (IC50 8 ug/ml), F. culmorum (IC50 5 ug/ml), F. oxysporum f.sp. lycopersici (I

Evidence 20 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 8 µg/mL

Target

Target Organism B. cinerea

Source & Reference

Database Source DRAMP

Other

Evidence Text

low salt medium A: active against A. brassicola (IC50 15 ug/ml), B. cinerea (IC50 8 ug/ml), F. culmorum (IC50 5 ug/ml), F. oxysporum f.sp. lycopersici (IC50 30 ug/ml), P. oryzae (I

Evidence 21 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 5 µg/mL

Target

Target Organism F. culmorum

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 22 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 30 µg/mL

Target

Target Organism p. lycopersici

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 23 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 0.3 µg/mL

Target

Target Organism P. oryzae

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 24 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 5 µg/mL

Target

Target Organism V. dahliae

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 25 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 15 µg/mL

Target

Target Organism A. brassicola

Source & Reference

Database Source DRAMP

Other

Evidence Text

0 ug/ml), P. oryzae (IC50 0.3 ug/ml), and V. dahliae (IC50 5 ug/ml). Active against fungi A. brassicola (IC50 15 ug/ml), B. cinerea (IC50 8 ug/ml), and F. culmorum (IC50 5 ug/ml).

Evidence 26 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 8 µg/mL

Target

Target Organism B. cinerea

Source & Reference

Database Source DRAMP

Other

Evidence Text

g/ml), and V. dahliae (IC50 5 ug/ml). Active against fungi A. brassicola (IC50 15 ug/ml), B. cinerea (IC50 8 ug/ml), and F. culmorum (IC50 5 ug/ml).

Evidence 27 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 5 µg/mL

Target

Target Organism F. culmorum

Source & Reference

Database Source DRAMP

Other

Evidence Text

g/ml). Active against fungi A. brassicola (IC50 15 ug/ml), B. cinerea (IC50 8 ug/ml), and F. culmorum (IC50 5 ug/ml).