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Peptide record

TPDB24440

Antibacterial Anticancer Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB24440
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
standard
No
A 20-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
QIIKKVRTWIKKAWHLIGKI
Physicochemical Analysis
C119H199N33O23
NDCEMFPSY
IK
2460.10
11.85
7
0
10
+6
1.54
-0.065
136.50
Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour
11000
447.14
2
Residue Composition
number
1
A
1
R
0
N
0
D
0
C
0
E
1
Q
1
G
1
H
5
I
1
L
5
K
0
M
0
F
0
P
0
S
1
T
2
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 1 I: 5 L: 1 K: 5 M: 0 F: 0 P: 0 S: 0 T: 1 W: 2 Y: 0 V: 1
Chemical Descriptors
20
C119H199N33O23
2460.10
11.85
+6
1.54
-0.065
Evidence Records 3 records
Evidence 1 Activity

Activity

EC50
Toxicity
17±1 µM
Cytotoxic
EC50 | 17±1 | µM | target cell: Human dermal microvascular endothelial cells HDME

Target

Human dermal microvascular endothelial cells HDME

Source & Reference

NA
DBAASP
In silico design and optimization of selective membranolytic anticancer peptides. | Sci Rep | 2019
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
>100 µM
Hemolytic Cytotoxic
50% Hemolysis | >100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
In silico design and optimization of selective membranolytic anticancer peptides. | Sci Rep | 2019
Evidence 3 Activity

Activity

HC50
Toxicity
100 µM
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: HC50>100 µM | Cytotoxicity: HDMEC: EC50=17 ± 1 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Sci Rep. 2019 Aug 2 9(1):11282.