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Peptide record

TPDB24439

Antibacterial Anticancer Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB24439
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
standard
No
A 20-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
QIIKKIRTWYRKAWHVLGKV
Physicochemical Analysis
C121H195N35O24
NDCEMFPS
K
2524.10
11.65
7
0
10
+6
1.11
-0.400
112.00
Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour
12490
494.83
3
Residue Composition
number
1
A
2
R
0
N
0
D
0
C
0
E
1
Q
1
G
1
H
3
I
1
L
4
K
0
M
0
F
0
P
0
S
1
T
2
W
1
Y
2
V
Amino Acid Distribution
A: 1 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 1 I: 3 L: 1 K: 4 M: 0 F: 0 P: 0 S: 0 T: 1 W: 2 Y: 1 V: 2
Chemical Descriptors
20
C121H195N35O24
2524.10
11.65
+6
1.11
-0.400
Evidence Records 3 records
Evidence 1 Activity

Activity

EC50
Toxicity
42±7 µM
Cytotoxic
EC50 | 42±7 | µM | target cell: Human dermal microvascular endothelial cells HDME

Target

Human dermal microvascular endothelial cells HDME

Source & Reference

NA
DBAASP
In silico design and optimization of selective membranolytic anticancer peptides. | Sci Rep | 2019
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
>200 µM
Hemolytic Cytotoxic
50% Hemolysis | >200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
In silico design and optimization of selective membranolytic anticancer peptides. | Sci Rep | 2019
Evidence 3 Activity

Activity

HC50
Toxicity
200 µM
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: HC50>200 µM | Cytotoxicity: HDMEC: EC50=42 ± 7 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Sci Rep. 2019 Aug 2 9(1):11282.