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Peptide record

TPDB24406

Antibacterial Antifungal Toxicity standard
119 amino acids
Basic Information
3D PDB MODEL
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TPDB24406
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia Antifungipept
standard
No
A 119-aa standard-residue multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from Peptipedia and Antifungipept, with an available 3D structural model.
Sequence
QDKGNADTRFLGGLGVPGGGVPGVGGGFLPGVPGHGGVVPGGGGNYCRTRYGYVCCKPGRCPQIRETCPGLRKGIPICRQDNECFGSDKCCFDTCLNDTVCKPIVAGFSGLLPGGQFEC
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C524H819N155O156S12
MW
G
12170.93
7.85
13
9
31
+3
1.05
-0.157
59.66
Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour
5220
0.43
30
Residue Composition
number
2
A
7
R
4
N
6
D
12
C
3
E
4
Q
28
G
1
H
4
I
7
L
5
K
0
M
6
F
11
P
2
S
5
T
0
W
3
Y
9
V
Amino Acid Distribution
A: 2 R: 7 N: 4 D: 6 C: 12 E: 3 Q: 4 G: 28 H: 1 I: 4 L: 7 K: 5 M: 0 F: 6 P: 11 S: 2 T: 5 W: 0 Y: 3 V: 9
Chemical Descriptors
119 reviewed residue count
C524H819N155O156S12 sequence-only estimate (linear, free termini)
12170.93 sequence-only estimate (linear, free termini)
7.85 sequence-only estimate (linear, free termini)
+3 sequence-only estimate (linear, free termini)
1.05 sequence-only estimate (linear, free termini)
-0.157 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2-10 µM

Target

Escherichia coli 363

Source & Reference

NA

Other

Active against Gram-positive S. aureus, M. luteus, and Gram-negative bacteria, E. coli 363 (MIC 2-10 uM). The peptide is helical based on CD studies ( Arayamethakorn S et al., 2016 ).
Evidence 2 Activity

Activity

MIC
Antifungal
2-10 µM

Target

Escherichia coli 363

Source & Reference

Antifungipept

Other

Active against Gram-positive S. aureus, M. luteus, and Gram-negative bacteria, E. coli 363 (MIC 2-10 uM). The peptide is helical based on CD studies ( Arayamethakorn S et al., 2016 ).