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Peptide record

TPDB24397

Anti-inflammatory peptide dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) Anti-inflammatory Antibacterial Antifungal Antihypertensive Bitter Toxicity iDPPIV standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB24397
Anti-inflammatory peptide dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
Anti-inflammatory Antibacterial Antifungal Antihypertensive Bitter Toxicity iDPPIV
Anti-infective peptides Cardiometabolic peptides Immunity and inflammation peptides Toxicity and safety peptides Food sensory peptides
Peptipedia CAFPdb dbAMP AHTPDB Tastepeptides-Meta iDPPIV
standard
No
A 2-aa standard natural multi-activity (Anti-inflammatory, Antibacterial, Antifungal, and other sources) peptide sequence curated from Peptipedia, CAFPdb, dbAMP, and other sources, with an available 3D structural model.
Sequence
PY
Physicochemical Analysis
C14H18N2O4
ARNDCEQGHILKMFSTWV
PY
278.31
5.94
0
0
1
-0
-0.49
-1.450
0.00
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
1490
535.38
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
1
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
2
C14H18N2O4
278.31
5.94
-0
-0.49
-1.450
278.3030
278.1262
Evidence Records 3 records
Evidence 1 Activity

Activity

EC50
Anti-inflammatory
0.00 µM
Anti-inflammatory
anti inflammatory
ai

Source & Reference

NA
Wang S., Zheng L., Zhao T., Zhang Q., Liu Y., Sun B., Su G., Zhao M.
Inhibitory effects of walnut (Juglans regia) peptides on neuroinflammation and oxidative stress in lipopolysaccharide-induced cognitive impairment mice. J. Agric. Food Chem., 68, 2381-2392, 2020
2020
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](CC1=CC=C(O)C=C1)(NC(=O)[C@]1([H])CCCN1)C(O)=O InChI=1S/C14H18N2O4/c17-10-5-3-9(4-6-10)8-12(14(19)20)16-13(18)11-2-1-7-15-11/h3-6,11-12,15,17H,1-2,7-8H2,(H,16,18)(H,19,20)/t11-,12-/m0/s1 InChIKey=OIDKVWTWGDWMHY-RYUDHWBXSA-N Insecticidal peptide according to the ChEMBL database Antinociceptive peptide according to the ChEMBL database Ligand of neurotensin receptor according to the ChEMBL database Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8866) Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 491) the ChEMBL database
Evidence 2 Activity

Activity

20% Killing
Toxicity
100 µg/mL
Cytotoxic
20% Killing | 100 | µg/mL | target cell: Vero cells

Target

Vero cells

Source & Reference

NA
DBAASP
In vitro antibacterial screening of six proline-based cyclic dipeptides in combination with ?-lactam antibiotics against medically important bacteria. | Appl Biochem Biotechnol | 2014
Evidence 3 Activity

Activity

IC50
iDPPIV
0.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Lan V. T. T., Ito K., Ohno M., Motoyama T., Ito S., Kawarasaki Y.
Analyzing a dipeptide library to identify human dipeptidyl peptidase IV inhibitor. Food Chemistry 175, 66-73, 2015
2015
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](CC1=CC=C(O)C=C1)(NC(=O)[C@]1([H])CCCN1)C(O)=O InChI=1S/C14H18N2O4/c17-10-5-3-9(4-6-10)8-12(14(19)20)16-13(18)11-2-1-7-15-11/h3-6,11-12,15,17H,1-2,7-8H2,(H,16,18)(H,19,20)/t11-,12-/m0/s1 InChIKey=OIDKVWTWGDWMHY-RYUDHWBXSA-N Insecticidal peptide according to the ChEMBL database Antinociceptive peptide according to the ChEMBL database Ligand of neurotensin receptor according to the ChEMBL database Anti-inflammatory peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9856) the EROP-Moscow database Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 491) the ChEMBL database
Additional Detail Fields 1 fields
2