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Peptide record

TPDB24375

Antibacterial Anticancer Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB24375
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CancerPPD 2.0
standard
No
A 24-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia and CancerPPD 2.0, with an available 3D structural model.
Sequence
PWRIRIRRRRIRIRWPPWRIRIRR
Physicochemical Analysis
C156H263N63O25
ANDCEQGHLKMFSTYV
R
3421.21
13.44
12
0
9
+12
3.66
-1.438
97.50
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
16500
482.29
0
Residue Composition
number
0
A
12
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
6
I
0
L
0
K
0
M
0
F
3
P
0
S
0
T
3
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 12 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 6 L: 0 K: 0 M: 0 F: 0 P: 3 S: 0 T: 0 W: 3 Y: 0 V: 0
Chemical Descriptors
24
C156H263N63O25
3421.21
13.44
+12
3.66
-1.438
Evidence Records 3 records
Evidence 1 Activity

Activity

LC50
Toxicity
14.5±0.1 µM
Cytotoxic
LC50 | 14.5±0.1 | µM | target cell: Human dermal fibroblasts

Target

Human dermal fibroblasts

Source & Reference

NA
DBAASP
Design of human lactoferricin derived antitumor peptides-activity and specificity against malignant melanoma in 2D and 3D model studies. | Biochim Biophys Acta | 2020
Evidence 2 Activity

Activity

LC50
Toxicity
7.3±0.1 µM
Cytotoxic
LC50 | 7.3±0.1 | µM | target cell: Human epidermal melanocytes

Target

Human epidermal melanocytes

Source & Reference

NA
DBAASP
Design of human lactoferricin derived antitumor peptides-activity and specificity against malignant melanoma in 2D and 3D model studies. | Biochim Biophys Acta | 2020
Evidence 3 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochim Biophys Acta Biomembr. 2020 Aug 1 1862(8):183267.