TPDB24345

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >300 µg/mL

Target

Target Organism E.coli MG1655

Source & Reference

Database Source NA

Other

Evidence Text

active against E.coli MG1655 (MIC >300 ug/ml), S.enterica ATCC 14028 (MIC >300 ug/ml), P.aeruginosa ATCC 27853 (MIC >300 ug/ml), B. cer

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >300 µg/mL

Target

Target Organism S.enterica ATCC 14028

Source & Reference

Database Source NA

Other

Evidence Text

active against E.coli MG1655 (MIC >300 ug/ml), S.enterica ATCC 14028 (MIC >300 ug/ml), P.aeruginosa ATCC 27853 (MIC >300 ug/ml), B. cereus ATCC 14893 (MIC 16 ug/ml), S. aureus

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >300 µg/mL

Target

Target Organism P.aeruginosa ATCC 27853

Source & Reference

Database Source NA

Other

Evidence Text

active against E.coli MG1655 (MIC >300 ug/ml), S.enterica ATCC 14028 (MIC >300 ug/ml), P.aeruginosa ATCC 27853 (MIC >300 ug/ml), B. cereus ATCC 14893 (MIC 16 ug/ml), S. aureus FDA 209 P (MIC 4 ug/ml), and L. monocytog

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 16 µg/mL

Target

Target Organism B. cereus ATCC 14893

Source & Reference

Database Source NA

Other

Evidence Text

ug/ml), S.enterica ATCC 14028 (MIC >300 ug/ml), P.aeruginosa ATCC 27853 (MIC >300 ug/ml), B. cereus ATCC 14893 (MIC 16 ug/ml), S. aureus FDA 209 P (MIC 4 ug/ml), and L. monocytogenes EGDe (MIC 32.5 ug/ml). Also, act

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µg/mL

Target

Target Organism Staphylococcus aureus FDA 209 P

Source & Reference

Database Source NA

Other

Evidence Text

00 ug/ml), P.aeruginosa ATCC 27853 (MIC >300 ug/ml), B. cereus ATCC 14893 (MIC 16 ug/ml), S. aureus FDA 209 P (MIC 4 ug/ml), and L. monocytogenes EGDe (MIC 32.5 ug/ml). Also, active against 4 strains S. aureus (MB

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 32.5 µg/mL

Target

Target Organism L. monocytogenes EGDe

Source & Reference

Database Source NA

Other

Evidence Text

>300 ug/ml), B. cereus ATCC 14893 (MIC 16 ug/ml), S. aureus FDA 209 P (MIC 4 ug/ml), and L. monocytogenes EGDe (MIC 32.5 ug/ml). Also, active against 4 strains S. aureus (MBC 12.5-25 ug/ml), 5 strains E. faecium (MBC

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µg/mL

Target

Target Organism A. niger ATCC 16404

Source & Reference

Database Source NA

Other

Evidence Text

497 (14 mm). Microdilution assays: The MIC values for EmiA were in the 0.5–4 ug/mL range: A. niger ATCC 16404 (MIC 4 ug/ml), A. niger 1133 m or 219 (MIC 4 ug/ml), A. terreus 3 K (MIC 0.5 ug/ml), A. terreus 497 (MI

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µg/mL

Target

Target Organism A. niger 1133 m or 219

Source & Reference

Database Source NA

Other

Evidence Text

The MIC values for EmiA were in the 0.5–4 ug/mL range: A. niger ATCC 16404 (MIC 4 ug/ml), A. niger 1133 m or 219 (MIC 4 ug/ml), A. terreus 3 K (MIC 0.5 ug/ml), A. terreus 497 (MIC 1 ug/ml), A. fumigatus VKM F-37 or 1

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.5 µg/mL

Target

Target Organism A. terreus 3 K

Source & Reference

Database Source NA

Other

Evidence Text

5–4 ug/mL range: A. niger ATCC 16404 (MIC 4 ug/ml), A. niger 1133 m or 219 (MIC 4 ug/ml), A. terreus 3 K (MIC 0.5 ug/ml), A. terreus 497 (MIC 1 ug/ml), A. fumigatus VKM F-37 or 163 (MIC 2 ug/ml), A. flavus 905

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1 µg/mL

Target

Target Organism A. terreus 497

Source & Reference

Database Source NA

Other

Evidence Text

6404 (MIC 4 ug/ml), A. niger 1133 m or 219 (MIC 4 ug/ml), A. terreus 3 K (MIC 0.5 ug/ml), A. terreus 497 (MIC 1 ug/ml), A. fumigatus VKM F-37 or 163 (MIC 2 ug/ml), A. flavus 905 (MIC 4 ug/ml), and A. fumigatu

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µg/mL

Target

Target Organism A. fumigatus VKM F-37 or 163

Source & Reference

Database Source NA

Other

Evidence Text

133 m or 219 (MIC 4 ug/ml), A. terreus 3 K (MIC 0.5 ug/ml), A. terreus 497 (MIC 1 ug/ml), A. fumigatus VKM F-37 or 163 (MIC 2 ug/ml), A. flavus 905 (MIC 4 ug/ml), and A. fumigatus 390 m (MIC 2 ug/ml). Since EmiA is more ac

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µg/mL

Target

Target Organism A. flavus 905

Source & Reference

Database Source NA

Other

Evidence Text

MIC 0.5 ug/ml), A. terreus 497 (MIC 1 ug/ml), A. fumigatus VKM F-37 or 163 (MIC 2 ug/ml), A. flavus 905 (MIC 4 ug/ml), and A. fumigatus 390 m (MIC 2 ug/ml). Since EmiA is more active, its activity was tested

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µg/mL

Target

Target Organism A. fumigatus 390 m

Source & Reference

Database Source NA

Other

Evidence Text

IC 1 ug/ml), A. fumigatus VKM F-37 or 163 (MIC 2 ug/ml), A. flavus 905 (MIC 4 ug/ml), and A. fumigatus 390 m (MIC 2 ug/ml). Since EmiA is more active, its activity was tested using additional multidrug-resistant

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µg/mL

Target

Target Organism Candida albicans 1402 or 1582 or ATCC14053

Source & Reference

Database Source NA

Other

Evidence Text

more active, its activity was tested using additional multidrug-resistant fungal strains: C. albicans 1402 or 1582 or ATCC14053 (MIC 2 ug/ml), C. glabrata 1402 (MIC 0.25 ug/ml), C. krusei 1447 (MIC 0.5 ug/ml), C. tropicalis 156 or

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.25 µg/mL

Target

Target Organism C. glabrata 1402

Source & Reference

Database Source NA

Other

Evidence Text

multidrug-resistant fungal strains: C. albicans 1402 or 1582 or ATCC14053 (MIC 2 ug/ml), C. glabrata 1402 (MIC 0.25 ug/ml), C. krusei 1447 (MIC 0.5 ug/ml), C. tropicalis 156 or 1402 (MIC 1-2 ug/ml), C. parapsilos

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.5 µg/mL

Target

Target Organism C. krusei 1447

Source & Reference

Database Source NA

Other

Evidence Text

: C. albicans 1402 or 1582 or ATCC14053 (MIC 2 ug/ml), C. glabrata 1402 (MIC 0.25 ug/ml), C. krusei 1447 (MIC 0.5 ug/ml), C. tropicalis 156 or 1402 (MIC 1-2 ug/ml), C. parapsilosis 571 (MIC 1 ug/ml), C. neoform

Evidence 17 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1-2 µg/mL

Target

Target Organism C. tropicalis 156 or 1402

Source & Reference

Database Source NA

Other

Evidence Text

CC14053 (MIC 2 ug/ml), C. glabrata 1402 (MIC 0.25 ug/ml), C. krusei 1447 (MIC 0.5 ug/ml), C. tropicalis 156 or 1402 (MIC 1-2 ug/ml), C. parapsilosis 571 (MIC 1 ug/ml), C. neoformans 297 (MIC 0.5 ug/ml), and C. laurentii 3

Evidence 18 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1 µg/mL

Target

Target Organism C. parapsilosis 571

Source & Reference

Database Source NA

Other

Evidence Text

C 0.25 ug/ml), C. krusei 1447 (MIC 0.5 ug/ml), C. tropicalis 156 or 1402 (MIC 1-2 ug/ml), C. parapsilosis 571 (MIC 1 ug/ml), C. neoformans 297 (MIC 0.5 ug/ml), and C. laurentii 325m (MIC 0.5 ug/ml). Anticancer act

Evidence 19 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.5 µg/mL

Target

Target Organism C. neoformans 297

Source & Reference

Database Source NA

Other

Evidence Text

0.5 ug/ml), C. tropicalis 156 or 1402 (MIC 1-2 ug/ml), C. parapsilosis 571 (MIC 1 ug/ml), C. neoformans 297 (MIC 0.5 ug/ml), and C. laurentii 325m (MIC 0.5 ug/ml). Anticancer activity: EmiA also has cytotoxic prop

Evidence 20 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.5 µg/mL

Target

Target Organism C. laurentii 325m

Source & Reference

Database Source NA

Other

Evidence Text

MIC 1-2 ug/ml), C. parapsilosis 571 (MIC 1 ug/ml), C. neoformans 297 (MIC 0.5 ug/ml), and C. laurentii 325m (MIC 0.5 ug/ml). Anticancer activity: EmiA also has cytotoxic properties towards a wide range of tumor ce

Evidence 21 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >300 µg/mL

Target

Target Organism E.coli MG1655

Source & Reference

Database Source NA

Other

Evidence Text

active against E.coli MG1655 (MIC >300 ug/ml), S.enterica ATCC 14028 (MIC >300 ug/ml), P.aeruginosa ATCC 27853 (MIC >300 ug/ml), B. cer

Evidence 22 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >300 µg/mL

Target

Target Organism S.enterica ATCC 14028

Source & Reference

Database Source NA

Other

Evidence Text

active against E.coli MG1655 (MIC >300 ug/ml), S.enterica ATCC 14028 (MIC >300 ug/ml), P.aeruginosa ATCC 27853 (MIC >300 ug/ml), B. cereus ATCC 14893 (MIC 16 ug/ml), S. aureus

Evidence 23 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >300 µg/mL

Target

Target Organism P.aeruginosa ATCC 27853

Source & Reference

Database Source NA

Other

Evidence Text

active against E.coli MG1655 (MIC >300 ug/ml), S.enterica ATCC 14028 (MIC >300 ug/ml), P.aeruginosa ATCC 27853 (MIC >300 ug/ml), B. cereus ATCC 14893 (MIC 16 ug/ml), S. aureus FDA 209 P (MIC 4 ug/ml), and L. monocytog

Evidence 24 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 16 µg/mL

Target

Target Organism B. cereus ATCC 14893

Source & Reference

Database Source NA

Other

Evidence Text

ug/ml), S.enterica ATCC 14028 (MIC >300 ug/ml), P.aeruginosa ATCC 27853 (MIC >300 ug/ml), B. cereus ATCC 14893 (MIC 16 ug/ml), S. aureus FDA 209 P (MIC 4 ug/ml), and L. monocytogenes EGDe (MIC 32.5 ug/ml). Also, act

Evidence 25 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4 µg/mL

Target

Target Organism Staphylococcus aureus FDA 209 P

Source & Reference

Database Source NA

Other

Evidence Text

00 ug/ml), P.aeruginosa ATCC 27853 (MIC >300 ug/ml), B. cereus ATCC 14893 (MIC 16 ug/ml), S. aureus FDA 209 P (MIC 4 ug/ml), and L. monocytogenes EGDe (MIC 32.5 ug/ml). Also, active against 4 strains S. aureus (MB

Evidence 26 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 32.5 µg/mL

Target

Target Organism L. monocytogenes EGDe

Source & Reference

Database Source NA

Other

Evidence Text

>300 ug/ml), B. cereus ATCC 14893 (MIC 16 ug/ml), S. aureus FDA 209 P (MIC 4 ug/ml), and L. monocytogenes EGDe (MIC 32.5 ug/ml). Also, active against 4 strains S. aureus (MBC 12.5-25 ug/ml), 5 strains E. faecium (MBC

Evidence 27 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4 µg/mL

Target

Target Organism A. niger ATCC 16404

Source & Reference

Database Source NA

Other

Evidence Text

497 (14 mm). Microdilution assays: The MIC values for EmiA were in the 0.5–4 ug/mL range: A. niger ATCC 16404 (MIC 4 ug/ml), A. niger 1133 m or 219 (MIC 4 ug/ml), A. terreus 3 K (MIC 0.5 ug/ml), A. terreus 497 (MI

Evidence 28 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4 µg/mL

Target

Target Organism A. niger 1133 m or 219

Source & Reference

Database Source NA

Other

Evidence Text

The MIC values for EmiA were in the 0.5–4 ug/mL range: A. niger ATCC 16404 (MIC 4 ug/ml), A. niger 1133 m or 219 (MIC 4 ug/ml), A. terreus 3 K (MIC 0.5 ug/ml), A. terreus 497 (MIC 1 ug/ml), A. fumigatus VKM F-37 or 1

Evidence 29 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 0.5 µg/mL

Target

Target Organism A. terreus 3 K

Source & Reference

Database Source NA

Other

Evidence Text

5–4 ug/mL range: A. niger ATCC 16404 (MIC 4 ug/ml), A. niger 1133 m or 219 (MIC 4 ug/ml), A. terreus 3 K (MIC 0.5 ug/ml), A. terreus 497 (MIC 1 ug/ml), A. fumigatus VKM F-37 or 163 (MIC 2 ug/ml), A. flavus 905

Evidence 30 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1 µg/mL

Target

Target Organism A. terreus 497

Source & Reference

Database Source NA

Other

Evidence Text

6404 (MIC 4 ug/ml), A. niger 1133 m or 219 (MIC 4 ug/ml), A. terreus 3 K (MIC 0.5 ug/ml), A. terreus 497 (MIC 1 ug/ml), A. fumigatus VKM F-37 or 163 (MIC 2 ug/ml), A. flavus 905 (MIC 4 ug/ml), and A. fumigatu

Evidence 31 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2 µg/mL

Target

Target Organism A. fumigatus VKM F-37 or 163

Source & Reference

Database Source NA

Other

Evidence Text

133 m or 219 (MIC 4 ug/ml), A. terreus 3 K (MIC 0.5 ug/ml), A. terreus 497 (MIC 1 ug/ml), A. fumigatus VKM F-37 or 163 (MIC 2 ug/ml), A. flavus 905 (MIC 4 ug/ml), and A. fumigatus 390 m (MIC 2 ug/ml). Since EmiA is more ac

Evidence 32 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4 µg/mL

Target

Target Organism A. flavus 905

Source & Reference

Database Source NA

Other

Evidence Text

MIC 0.5 ug/ml), A. terreus 497 (MIC 1 ug/ml), A. fumigatus VKM F-37 or 163 (MIC 2 ug/ml), A. flavus 905 (MIC 4 ug/ml), and A. fumigatus 390 m (MIC 2 ug/ml). Since EmiA is more active, its activity was tested

Evidence 33 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2 µg/mL

Target

Target Organism A. fumigatus 390 m

Source & Reference

Database Source NA

Other

Evidence Text

IC 1 ug/ml), A. fumigatus VKM F-37 or 163 (MIC 2 ug/ml), A. flavus 905 (MIC 4 ug/ml), and A. fumigatus 390 m (MIC 2 ug/ml). Since EmiA is more active, its activity was tested using additional multidrug-resistant

Evidence 34 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2 µg/mL

Target

Target Organism Candida albicans 1402 or 1582 or ATCC14053

Source & Reference

Database Source NA

Other

Evidence Text

more active, its activity was tested using additional multidrug-resistant fungal strains: C. albicans 1402 or 1582 or ATCC14053 (MIC 2 ug/ml), C. glabrata 1402 (MIC 0.25 ug/ml), C. krusei 1447 (MIC 0.5 ug/ml), C. tropicalis 156 or

Evidence 35 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 0.25 µg/mL

Target

Target Organism C. glabrata 1402

Source & Reference

Database Source NA

Other

Evidence Text

multidrug-resistant fungal strains: C. albicans 1402 or 1582 or ATCC14053 (MIC 2 ug/ml), C. glabrata 1402 (MIC 0.25 ug/ml), C. krusei 1447 (MIC 0.5 ug/ml), C. tropicalis 156 or 1402 (MIC 1-2 ug/ml), C. parapsilos

Evidence 36 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 0.5 µg/mL

Target

Target Organism C. krusei 1447

Source & Reference

Database Source NA

Other

Evidence Text

: C. albicans 1402 or 1582 or ATCC14053 (MIC 2 ug/ml), C. glabrata 1402 (MIC 0.25 ug/ml), C. krusei 1447 (MIC 0.5 ug/ml), C. tropicalis 156 or 1402 (MIC 1-2 ug/ml), C. parapsilosis 571 (MIC 1 ug/ml), C. neoform

Evidence 37 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1-2 µg/mL

Target

Target Organism C. tropicalis 156 or 1402

Source & Reference

Database Source NA

Other

Evidence Text

CC14053 (MIC 2 ug/ml), C. glabrata 1402 (MIC 0.25 ug/ml), C. krusei 1447 (MIC 0.5 ug/ml), C. tropicalis 156 or 1402 (MIC 1-2 ug/ml), C. parapsilosis 571 (MIC 1 ug/ml), C. neoformans 297 (MIC 0.5 ug/ml), and C. laurentii 3

Evidence 38 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1 µg/mL

Target

Target Organism C. parapsilosis 571

Source & Reference

Database Source NA

Other

Evidence Text

C 0.25 ug/ml), C. krusei 1447 (MIC 0.5 ug/ml), C. tropicalis 156 or 1402 (MIC 1-2 ug/ml), C. parapsilosis 571 (MIC 1 ug/ml), C. neoformans 297 (MIC 0.5 ug/ml), and C. laurentii 325m (MIC 0.5 ug/ml). Anticancer act

Evidence 39 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 0.5 µg/mL

Target

Target Organism C. neoformans 297

Source & Reference

Database Source NA

Other

Evidence Text

0.5 ug/ml), C. tropicalis 156 or 1402 (MIC 1-2 ug/ml), C. parapsilosis 571 (MIC 1 ug/ml), C. neoformans 297 (MIC 0.5 ug/ml), and C. laurentii 325m (MIC 0.5 ug/ml). Anticancer activity: EmiA also has cytotoxic prop

Evidence 40 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 0.5 µg/mL

Target

Target Organism C. laurentii 325m

Source & Reference

Database Source NA

Other

Evidence Text

MIC 1-2 ug/ml), C. parapsilosis 571 (MIC 1 ug/ml), C. neoformans 297 (MIC 0.5 ug/ml), and C. laurentii 325m (MIC 0.5 ug/ml). Anticancer activity: EmiA also has cytotoxic properties towards a wide range of tumor ce