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Peptide record

TPDB24311

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) Antibacterial Antifungal Toxicity iDPPIV standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB24311
dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
Antibacterial Antifungal Toxicity iDPPIV
Anti-infective peptides Cardiometabolic peptides Toxicity and safety peptides
Peptipedia CAFPdb dbAMP iDPPIV
standard
No
A 2-aa standard natural multi-activity (Antibacterial, Antifungal, Toxicity, and other sources) peptide sequence curated from Peptipedia, CAFPdb, dbAMP, and other sources, with an available 3D structural model.
Sequence
PM
Physicochemical Analysis
C10H18N2O3S1
ARNDCEQGHILKFSTWYV
MP
246.32
6.02
0
0
1
-0
0.22
0.150
0.00
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
1
M
0
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 1 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
2
C10H18N2O3S1
246.32
6.02
-0
0.22
0.150
246.3269
246.1034
Evidence Records 2 records
Evidence 1 Activity

Activity

15% Killing
Toxicity
100 µg/mL
Cytotoxic
15% Killing | 100 | µg/mL | target cell: Vero cells

Target

Vero cells

Source & Reference

NA
DBAASP
In vitro antibacterial screening of six proline-based cyclic dipeptides in combination with ?-lactam antibiotics against medically important bacteria. | Appl Biochem Biotechnol | 2014
Evidence 2 Activity

Activity

IC50
iDPPIV
0.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Lan V. T. T., Ito K., Ohno M., Motoyama T., Ito S., Kawarasaki Y.
Analyzing a dipeptide library to identify human dipeptidyl peptidase IV inhibitor. Food Chemistry 175, 66-73, 2015
2015
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCSC)C(=O)O InChI=1S/C10H18N2O3S/c1-16-6-4-8(10(14)15)12-9(13)7-3-2-5-11-7/h7-8,11H,2-6H2,1H3,(H,12,13)(H,14,15)/t7-,8-/m0/s1 InChIKey=MTWJTFBVRDGROD-YUMQZZPRSA-N Inhibitor of Angiotensin-converting enzyme (ACE) (EC 3.4.15.1) (MEROPS ID M02-001) according to the BRENDA database the EROP-Moscow database
Additional Detail Fields 1 fields
2