TPDB

3D PDB MODEL

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TPDB ID TPDB24308

Activity

Antibacterial Anticancer Antifungal Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

Peptipedia CancerPPD 2.0 dbACP Antifungipept CAFPdb dbAMP

Sequence_Type

standard

Has_Modification No

Description A 46-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, CancerPPD 2.0, dbACP, and other sources, with an available 3D structural model.

Sequence

PMPVSQECFETLRGHERILSILRHQNLLKELQDLALQGAKERAHQQ

FASTA

>TPDB24308|Antibacterial;Anticancer;Antifungal;Toxicity|length=46
PMPVSQECFETLRGHERILSILRHQNLLKELQDLALQGAKERAHQQ

Formula C232H383N73O69S2

Absent Amino Acids WY

Common Amino Acids L

Mass 5363.16

PI 7.41

Basic Residues 9

Acidic Residues 6

Hydrophobic Residues 16

Net Charge +0

Boman Index 17.51

Hydrophobicity -0.674

Aliphatic Index 97.61

Half Life

Mammalian: >20 hour Yeast: >20 hour E.coli: ?

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 11

number

3

A

4

R

1

N

1

D

1

C

5

E

6

Q

2

G

3

H

2

I

8

L

2

K

1

M

1

F

2

P

2

S

1

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 3 R: 4 N: 1 D: 1 C: 1 E: 5 Q: 6 G: 2 H: 3 I: 2 L: 8 K: 2 M: 1 F: 1 P: 2 S: 2 T: 1 W: 0 Y: 0 V: 1

Length

46

Formula

C232H383N73O69S2

Mass

5363.16

PI

7.41

Net Charge

+0

Boman Index

17.51

Hydrophobicity

-0.674

Evidence 1 Activity

Activity

Detail Source Activity Antibacterial

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

Active against C. albicans, C. glabrata, C. parapsilosis, C. krusei, and C. tropicalis at a concentration MIC Li RF et al., 2015 ). It also inhibits the growth of lung cancer A549 cells.

Evidence 2 Activity

Activity

Detail Source Activity Antifungal

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

Active against C. albicans, C. glabrata, C. parapsilosis, C. krusei, and C. tropicalis at a concentration MIC Li RF et al., 2015 ). It also inhibits the growth of lung cancer A549 cells.

Evidence 3 Activity

Activity

Activity Endpoint 5% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 740 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

5% Hemolysis | 740 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Molecular Design, Structural Analysis and Antifungal Activity of Derivatives of Peptide CGA-N46. | Interdiscip Sci | 2016