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Peptide record

TPDB24299

ACE inhibitor from Alaskan pollack skin dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) ACE inhibitors Antibacterial Anticancer Antifungal Antihypertensive Bitter Toxicity iDPPIV standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB24299
ACE inhibitor from Alaskan pollack skin dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
ACE inhibitors Antibacterial Anticancer Antifungal Antihypertensive Bitter Toxicity iDPPIV
Anti-infective peptides Cardiometabolic peptides Cancer-related peptides Toxicity and safety peptides Food sensory peptides
Peptipedia CAFPdb AHTPDB AHTpin Tastepeptides-Meta iDPPIV
standard
No
A 2-aa standard natural multi-activity (ACE inhibitors, Antibacterial, Anticancer, and other sources) peptide sequence curated from Peptipedia, CAFPdb, AHTPDB, and other sources, with an available 3D structural model.
Sequence
PL
Physicochemical Analysis
C11H20N2O3
ARNDCEQGHIKMFSTWYV
LP
228.29
6.02
0
0
1
-0
-0.11
1.100
195.00
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
0
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
2
C11H20N2O3
228.29
6.02
-0
-0.11
1.100
228.2873
228.1469
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
337.32 µM
Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Byun H.-G., Kim S.-K.
Structure and activity of angiotensin I-converting enzyme inhibitory peptides derived from Alaskan pollack skin. Bioch. Mol. Biol., 35, 2, 239-243, 2002
2002
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N1[C@H](C(=O)N[C@H](C(=O)O)CC(C)C)CCC1 InChI=1S/C11H20N2O3/c1-7(2)6-9(11(15)16)13-10(14)8-4-3-5-12-8/h7-9,12H,3-6H2,1-2H3,(H,13,14)(H,15,16)/t8-,9-/m0/s1 InChIKey: ZKQOUHVVXABNDG-IUCAKERBSA-N Inhibitof of Xaa-Pro aminopeptidase (EC 3.4.11.9) (MEROPS ID: M24.005) according to BRENDA database MMDB database Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to BIOPEP-UWM database of bioactive peptides (ID 8638) BRENDA database Inhibitor of Lactocepin (EC 3.4.21.96) (MEROPS ID: S08.019) according to BRENDA database Bitter peptide according to BIOPEP database of sensory peptides and amino acids (ID 347) ChEMBL database PubChem database
Evidence 2 Activity

Activity

IC50
Antihypertensive
337.32 µM
Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Byun H.-G., Kim S.-K.
Structure and activity of angiotensin I-converting enzyme inhibitory peptides derived from Alaskan pollack skin. Bioch. Mol. Biol., 35, 2, 239-243, 2002
2002
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
2
BIOPEP-UWM database of bioactive peptides SMILES: N1[C@H](C(=O)N[C@H](C(=O)O)CC(C)C)CCC1 InChI=1S/C11H20N2O3/c1-7(2)6-9(11(15)16)13-10(14)8-4-3-5-12-8/h7-9,12H,3-6H2,1-2H3,(H,13,14)(H,15,16)/t8-,9-/m0/s1 InChIKey: ZKQOUHVVXABNDG-IUCAKERBSA-N Inhibitof of Xaa-Pro aminopeptidase (EC 3.4.11.9) (MEROPS ID: M24.005) according to BRENDA database MMDB database Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to BIOPEP-UWM database of bioactive peptides (ID 8638) BRENDA database Inhibitor of Lactocepin (EC 3.4.21.96) (MEROPS ID: S08.019) according to BRENDA database Bitter peptide according to BIOPEP database of sensory peptides and amino acids (ID 347) ChEMBL database PubChem database
Evidence 3 Activity

Activity

IC50
iDPPIV
0.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Gallego M., Aristoy M.-C., Toldrá F.
Dipeptidyl peptidase IV inhibitory peptides generated in Spanish dry-cured ham. Meat Science 96, 757-761, 2014
2014
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N1[C@H](C(=O)N[C@H](C(=O)O)CC(C)C)CCC1 InChI=1S/C11H20N2O3/c1-7(2)6-9(11(15)16)13-10(14)8-4-3-5-12-8/h7-9,12H,3-6H2,1-2H3,(H,13,14)(H,15,16)/t8-,9-/m0/s1 InChIKey: ZKQOUHVVXABNDG-IUCAKERBSA-N Inhibitof of Xaa-Pro aminopeptidase (EC 3.4.11.9) (MEROPS ID: M24.005) according to BRENDA database MMDB database Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001) according to AHTPDB database BIOPEP-UWM database of bioactive peptides (ID 7513) BRENDA database SATPdb database Inhibitor of Lactocepin (EC 3.4.21.96) (MEROPS ID: S08.019) according to BRENDA database Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 367) ChEMBL database PubChem database
Additional Detail Fields 1 fields
2