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Peptide record

TPDB24273

ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) ACE inhibitors Antibacterial Anticancer Antifungal Antihypertensive Toxicity iDPPIV standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB24273
ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
ACE inhibitors Antibacterial Anticancer Antifungal Antihypertensive Toxicity iDPPIV
Anti-infective peptides Cardiometabolic peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia AHTPDB AHTpin iDPPIV
standard
No
A 2-aa standard natural multi-activity (ACE inhibitors, Antibacterial, Anticancer, and other sources) peptide sequence curated from Peptipedia, AHTPDB, AHTpin, and other sources, with an available 3D structural model.
Sequence
PG
Physicochemical Analysis
C7H12N2O3
ARNDCEQHILKMFSTWYV
GP
172.18
6.02
0
0
0
-0
0.46
-1.000
0.00
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
2
C7H12N2O3
172.18
6.02
-0
0.46
-1.000
172.1813
172.0845
Evidence Records 5 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
17000.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Cheung H. S., Wang F. L., Ondetti M. A., Sabo E. F., Cushman D. W.
Binding of peptide substarates and inhibitors of angiotensin-converting enzyme. Journal of Biological Chemistry, 255, 401-407
1980
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N1[C@@]([H])(CCC1)C(=O)NCC(=O)O InChI=1S/C7H12N2O3/c10-6(11)4-9-7(12)5-2-1-3-8-5/h5,8H,1-4H2,(H,9,12)(H,10,11)/t5-/m0/s1 InChIKey: RNKSNIBMTUYWSH-YFKPBYRVSA-N Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8855) the BRENDA database Antithrombotic peptide according to the BIOPEP-UWM database of bioactive peptides (ID 3285) Inhibitor of Prolyl Endopeptidase (PEP) (EC 3.4.21.26) (MEROPS ID: S09.001) according to the BIOPEP-UWM database of bioactive peptides (ID 3460) the EROP-Moscow database (ID E02533) Peptide regulating the stomach mucosal membrane activity according to the BIOPEP-UWM database of bioactive peptides (ID 2754) Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 481), the ChEMBL database the EROP-Moscow database (ID E03694)
Evidence 2 Activity

Activity

IC50
Antihypertensive
17000.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Cheung H. S., Wang F. L., Ondetti M. A., Sabo E. F., Cushman D. W.
Binding of peptide substarates and inhibitors of angiotensin-converting enzyme. Journal of Biological Chemistry, 255, 401-407
1980
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
2
BIOPEP-UWM database of bioactive peptides SMILES: N1[C@@]([H])(CCC1)C(=O)NCC(=O)O InChI=1S/C7H12N2O3/c10-6(11)4-9-7(12)5-2-1-3-8-5/h5,8H,1-4H2,(H,9,12)(H,10,11)/t5-/m0/s1 InChIKey: RNKSNIBMTUYWSH-YFKPBYRVSA-N Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8855) the BRENDA database Antithrombotic peptide according to the BIOPEP-UWM database of bioactive peptides (ID 3285) Inhibitor of Prolyl Endopeptidase (PEP) (EC 3.4.21.26) (MEROPS ID: S09.001) according to the BIOPEP-UWM database of bioactive peptides (ID 3460) the EROP-Moscow database (ID E02533) Peptide regulating the stomach mucosal membrane activity according to the BIOPEP-UWM database of bioactive peptides (ID 2754) Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 481), the ChEMBL database the EROP-Moscow database (ID E03694)
Evidence 3 Activity

Activity

IC50
Toxicity
3.96±0.51 µM
Cytotoxic
IC50 | 3.96±0.51 | µM | target cell: Mouse fibroblasts BALB/3T3

Target

Mouse fibroblasts BALB/3T3

Source & Reference

NA
DBAASP
Synthesis and biological evaluation of new amino acid and dipeptide derivatives of neocryptolepine as anticancer agents. | J Med Chem | 2012
Evidence 4 Activity

Activity

10% Hemolysis
Toxicity
300 µM
Hemolytic Cytotoxic
10% Hemolysis | 300 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Synthesis and biological evaluation of new amino acid and dipeptide derivatives of neocryptolepine as anticancer agents. | J Med Chem | 2012
Evidence 5 Activity

Activity

IC50
iDPPIV
0.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Lan V. T. T., Ito K., Ohno M., Motoyama T., Ito S., Kawarasaki Y.
Analyzing a dipeptide library to identify human dipeptidyl peptidase IV inhibitor. Food Chemistry, 175, 66-73, 2015
2015
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N1[C@@]([H])(CCC1)C(=O)NCC(=O)O InChI=1S/C7H12N2O3/c10-6(11)4-9-7(12)5-2-1-3-8-5/h5,8H,1-4H2,(H,9,12)(H,10,11)/t5-/m0/s1 InChIKey: RNKSNIBMTUYWSH-YFKPBYRVSA-N Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database, the BindingDB database the BIOPEP-UWM database of bioactive peptides (ID 7625) the ChEMBL database the EROP-Moscow database (ID E09277) Antithrombotic peptide according to the BIOPEP-UWM database of bioactive peptides (ID 3285) Inhibitor of Prolyl Endopeptidase (PEP) (EC 3.4.21.26) (MEROPS ID: S09.001) according to the BIOPEP-UWM database of bioactive peptides (ID 3460) the EROP-Moscow database (ID E02533) Peptide regulating the stomach mucosal membrane activity according to the BIOPEP-UWM database of bioactive peptides (ID 2754) Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 481), the ChEMBL database the EROP-Moscow database (ID E03694)
Additional Detail Fields 1 fields
2