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Peptide record

TPDB24271

Antibacterial Anticancer Toxicity standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB24271
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CancerPPD 2.0
standard
No
A 22-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia and CancerPPD 2.0, with an available 3D structural model.
Sequence
PFWRRRIRIRRRRIRIRRRWFP
Physicochemical Analysis
C146H242N60O23
ANDCEQGHLKMSTYV
R
3205.92
13.44
12
0
8
+12
3.42
-1.609
70.91
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
11000
343.12
0
Residue Composition
number
0
A
12
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
4
I
0
L
0
K
0
M
2
F
2
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 12 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 4 L: 0 K: 0 M: 0 F: 2 P: 2 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
22
C146H242N60O23
3205.92
13.44
+12
3.42
-1.609
Evidence Records 2 records
Evidence 1 Activity

Activity

LC50
Toxicity
22.8±0.1 µM
Cytotoxic
LC50 | 22.8±0.1 | µM | target cell: Human dermal fibroblasts

Target

Human dermal fibroblasts

Source & Reference

NA
DBAASP
Human lactoferricin derived di-peptides deploying loop structures induce apoptosis specifically in cancer cells through targeting membranous phosphatidylserine. | Biochim Biophys Acta | 2015
Evidence 2 Activity

Activity

LC50
Toxicity
22.8
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Normal Human Dermal Fibroblasts (NHDF): LC50=22.8±0.1 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochim Biophys Acta. 2015 Nov 1848(11 Pt A):2918-31.