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Peptide record

TPDB24268

PFV PTD Tf-PFV PF4 Antibacterial Antiviral Blood-Brain Barrier Cell-penetrating Peptides standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB24268
PFV PTD Tf-PFV PF4
Antibacterial Antiviral Blood-Brain Barrier Cell-penetrating Peptides
Anti-infective peptides Delivery and barrier-penetrating peptides
Peptipedia dbAMP 3.0 DRAVP 2.0 B3Pred BBPpredict CellPPD CellPPD-MOD CPPsite3.0 MLCPP 2.0 PerseuCPP
standard
No
A 6-aa standard natural multi-activity (Antibacterial, Antiviral, Blood-Brain Barrier, and other sources) peptide sequence curated from Peptipedia, dbAMP 3.0, DRAVP 2.0, and other sources, with an available 3D structural model.
Sequence
PFVYLI
Physicochemical Analysis
C40H58N6O8
ARNDCEQGHKMSTW
ILFPYV
750.94
5.94
0
0
5
-0
-2.42
2.067
178.33
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
1490
198.42
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
1
L
0
K
0
M
1
F
1
P
0
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 1 K: 0 M: 0 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
6
C40H58N6O8
750.94
5.94
-0
-2.42
2.067
Free
L
Linear
Neutral Hydrophobic
Linear
Free
Similarity
Cationic
ProPheValTyrLeuIle
N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)O N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)O
Evidence Records 5 records
Evidence 1 Activity

Activity

Blood-Brain Barrier

Target

Glioblastoma (U87), brain endothelial (bEnd.3), an

Assay & Model

By measuring the flux of sodium fluorescence (Na-F) and TEER
The transport of Tf-PFV liposomes across the endothelial barrier layer into tumor grown in the porou
Origin/Source
Glioblastoma multiforme

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
The dual functionalized liposomes showed significantly higher cellular uptake as well as increased t
Transcytosis
Combination with the transferrin protein
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

MCF-7, HeLa, Hepg2 And MCF-7/Adr Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Neutral
Synthetic
Cytosol
CsA internalization was 4.7-fold higher for PFV and 6.8-fold higher for VPT in HeLa cells 5.6-fold higher for PFV and 19.1-fold higher for VPT in MCF-7 cells
In vitro
CCCCCC
Evidence 3 Activity

Activity

Cell-penetrating Peptides

Target

K-562 ,Sco2/Cox-Deficient Fibroblasts, Bm-Nucleated Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Synthetic
IVT-mRNA of SCO2 and β-globin
Efficient delivery of PTD-IVT-mRNA of SCO2 was confirmed in 30 min
Clathrin mediated endocytosis
In vitro
CCGGGTSCC
Evidence 4 Activity

Activity

Cell-penetrating Peptides

Target

MCF-7

Assay & Model

Female BALB/c nude mice of 18–20 g
Female BALB/c nude mice of 18–20 g

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Hydrophobic
Protein derived
Cou6-nanoliposomes loaded paclitaxel (PTX)
Cytoplasm
Cou6 level for PFV-Lip-Cou6 was 2.3-fold higher than that of Lip-Cou6
In vitro and in vivo
CCCCSHHHHTTSCCCCSSCCCSCC
Evidence 5 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Non-natural residues Linear L Hydrophobic
Protein derived
pHPMA polymer
Cytoplasm
About 4 to 5 times higher concentration than the control polymer REF
Endocytosis
In vitro
Additional Detail Fields 1 fields
CCCCCC CCGGGTSCC CCCCSHHHHTTSCCCCSSCCCSCC