TPDB

3D PDB MODEL

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TPDB ID TPDB24259

Peptide_Name

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)

Activity

Antibacterial Anticancer Antifungal Antihypertensive Bitter Toxicity iDPPIV

Activity_category_statistics

Anti-infective peptides Cardiometabolic peptides Cancer-related peptides Toxicity and safety peptides Food sensory peptides

Database_Source

Peptipedia CAFPdb dbAMP AHTPDB Tastepeptides-Meta iDPPIV

Sequence_Type

standard

Has_Modification No

Description A 2-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, CAFPdb, dbAMP, and other sources, with an available 3D structural model.

Sequence

PF

FASTA

>TPDB24259|Antibacterial;Anticancer;Antifungal;Antihypertensive;Bitter;Toxicity;iDPPIV|length=2
PF

Formula C14H18N2O3

Absent Amino Acids ARNDCEQGHILKMSTWYV

Common Amino Acids FP

Mass 262.31

PI 6.02

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 1

Net Charge -0

Boman Index -0.68

Hydrophobicity 0.600

Aliphatic Index 0.00

Half Life

Mammalian: >20 hour Yeast: >20 hour E.coli: ?

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

0

I

0

L

0

K

0

M

1

F

1

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

2

Formula

C14H18N2O3

Mass

262.31

PI

6.02

Net Charge

-0

Boman Index

-0.68

Hydrophobicity

0.600

Chemical_Mass

262.3036

Monoisotopic_Mass

262.1313

Evidence 1 Activity

Activity

Activity Endpoint 18% Killing

Detail Source Activity Toxicity

Activity Measurement 100 µg/mL

Toxicity Type Cytotoxic

Toxicity Raw

18% Killing | 100 | µg/mL | target cell: Vero cells

Target

Target Cell Vero cells

Source & Reference

Database Source NA

Source Database DBAASP

Reference

In vitro antibacterial screening of six proline-based cyclic dipeptides in combination with ?-lactam antibiotics against medically important bacteria. | Appl Biochem Biotechnol | 2014

Evidence 2 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Biomed Res Int. 2015 2015:197608.

Evidence 3 Activity

Activity

Activity Endpoint IC50

Detail Source Activity iDPPIV

Activity Measurement 0.00 µM

Function Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)

Detail Activity dipeptidyl peptidase IV inhibitor

Activity Code dpp

Source & Reference

Database Source iDPPIV

Authors Lan V. T. T., Ito K., Ohno M., Motoyama T., Ito S., Kawarasaki Y.

Title Analyzing a dipeptide library to identify human dipeptidyl peptidase IV inhibitor. Food Chemistry 175, 66-73, 2015

Year 2015

Literature Source Journal

Other

Number of Residues 2

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N1[C@H](C(=O)N[C@H](C(=O)O)Cc2ccccc2)CCC1 InChI=1S/C14H18N2O3/c17-13(11-7-4-8-15-11)16-12(14(18)19)9-10-5-2-1-3-6-10/h1-3,5-6,11-12,15H,4,7-9H2,(H,16,17)(H,18,19)/t11-,12-/m0/s1 InChIKey: IWIANZLCJVYEFX-RYUDHWBXSA-N Inhibitor of angiotensin-converting enzyme (EC 3.4.15.1 MEROPS ID: M02-001) according to the AHTPDB database Inhibitor of dipeptidyl-peptidase III (EC 3.4.14.4 MEROPS ID M49.001) according to the BIOPEP-UWM database of bioactive peptides (ID 9505) the BRENDA database Inhibitor of angiotensin-converting enzyme 2 (EC 3.4.17.23 MEROPS ID: M02.006) according to the BRENDA database the EROP-Moscow database (ID E03992) Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids the ChEMBL database the PubChem database

Number_of_Residues

2