TPDB

3D PDB MODEL

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TPDB ID TPDB24246

Peptide_Name

Peptide 2b

Activity

Antibacterial Anticancer Antidiabetic Antifungal

Activity_category_statistics

Anti-infective peptides Cardiometabolic peptides Cancer-related peptides

Database_Source

Peptipedia CancerPPD 2.0

Sequence_Type

standard

Has_Modification No

Description A 2-aa standard natural multi-activity (Antibacterial, Anticancer, Antidiabetic, and other sources) peptide sequence curated from Peptipedia and CancerPPD 2.0, with an available 3D structural model.

Modification

N-terminal: 4-azidobenzoic acid

Sequence

PE

FASTA

>TPDB24246|Antibacterial;Anticancer;Antidiabetic;Antifungal|length=2
PE

Formula C10H16N2O5

Absent Amino Acids ARNDCQGHILKMFSTWYV

Common Amino Acids EP

Mass 244.25

PI 3.29

Basic Residues 0

Acidic Residues 1

Hydrophobic Residues 0

Net Charge -1

Boman Index 2.47

Hydrophobicity -2.550

Aliphatic Index 0.00

Half Life

Mammalian: >20 hour Yeast: >20 hour E.coli: ?

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

0

A

0

R

0

N

0

D

0

C

1

E

0

Q

0

G

0

H

0

I

0

L

0

K

0

M

0

F

1

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

2

Formula

C10H16N2O5

Mass

244.25

PI

3.29

Net Charge

-1

Boman Index

2.47

Hydrophobicity

-2.550

C_terminal_Modification

Free

Chirality

L

Linear_or_Cyclic

Linear

N_terminal_Modification

4-azidobenzoic acid

Nature

Antiproliferative, Anticancer

Origin

Synthetic

Evidence 1 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 12.1 ± 0.23 µM

Detail Source Activity Anticancer

Activity Measurement 12.1

Target

Cancer Type Breast Cancer

Cell Line MCF-7

Tissue Affected Breast

Assay & Model

Assay MTT assay

Testing Time 48-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2017

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 2 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 19.3 ± 0.02 µM

Detail Source Activity Anticancer

Activity Measurement 19.3

Target

Cancer Type Liver Cancer

Cell Line HepG-2

Tissue Affected Liver

Assay & Model

Assay MTT assay

Testing Time 48-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2017

Evidence 3 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 19.9 ± 0.03 µM

Detail Source Activity Anticancer

Activity Measurement 19.9

Target

Cancer Type Lung Cancer

Cell Line A-549

Tissue Affected Lung

Assay & Model

Assay MTT assay

Testing Time 48-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2017

Evidence 4 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 17.7 ± 0.04 µM

Detail Source Activity Anticancer

Activity Measurement 17.7

Target

Cancer Type Cervical Cancer

Cell Line HeLa

Tissue Affected Cervix

Assay & Model

Assay MTT assay

Testing Time 48-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2017