Back to search

Peptide record

TPDB24212

Anti-inflammatory Antibacterial Antifungal Toxicity standard
91 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB24212
Anti-inflammatory Antibacterial Antifungal Toxicity
Anti-infective peptides Immunity and inflammation peptides Toxicity and safety peptides
Peptipedia AFP-GFuse Antifungipept CAFPdb dbAMP
standard
No
A 91-aa standard natural multi-activity (Anti-inflammatory, Antibacterial, Antifungal, and other sources) peptide sequence curated from Peptipedia, AFP-GFuse, Antifungipept, and other sources, with an available 3D structural model.
Sequence
NWYVKKCLNDVGICKKKCKPEEMHVKNGWAMCGKQRDCCVPADRRANYPVFCVQTKTTRISTVTATTATTTLMMTTASMSSMAPTPVSPTG
Physicochemical Analysis
C426H698N122O129S13
T
10009.75
9.45
14
5
30
+8
16.89
-0.326
50.33
Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour
14355
143.41
34
Residue Composition
number
7
A
4
R
4
N
3
D
7
C
2
E
2
Q
4
G
1
H
2
I
2
L
9
K
6
M
1
F
6
P
5
S
14
T
2
W
2
Y
8
V
Amino Acid Distribution
A: 7 R: 4 N: 4 D: 3 C: 7 E: 2 Q: 2 G: 4 H: 1 I: 2 L: 2 K: 9 M: 6 F: 1 P: 6 S: 5 T: 14 W: 2 Y: 2 V: 8
Chemical Descriptors
91
C426H698N122O129S13
10009.75
9.45
+8
16.89
-0.326
Evidence Records 2 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
The core defensin region (sequence: NWYVKKCLNDVGICKKKCKPEEMHVKNGWAMCGKQRDCCVPAD) was recombinantly expressed in 2013 and found to have antimicrobial activity against E. coli K12D31, S. aureus CMCC 26003, and C. albicans SC 5314 (see the ref). This form also has moderate LPS binding ability, thereby anti-inflammatory in nature.
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
The core defensin region (sequence: NWYVKKCLNDVGICKKKCKPEEMHVKNGWAMCGKQRDCCVPAD) was recombinantly expressed in 2013 and found to have antimicrobial activity against E. coli K12D31, S. aureus CMCC 26003, and C. albicans SC 5314 (see the ref). This form also has moderate LPS binding ability, thereby anti-inflammatory in nature.