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Peptide record

TPDB24099

Antibacterial Anticancer Antifungal Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB24099
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF CAFPdb
standard
No
A 15-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, ACP740 _ACP240, AntiCP 2.0, and other sources, with an available 3D structural model.
Sequence
NKWKKILGKIIKVVK
Physicochemical Analysis
C87H155N23O17
ARDCEQHMFPSTY
K
1795.33
11.21
6
0
7
+6
3.17
-0.167
142.67
Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour
5500
306.35
1
Residue Composition
number
0
A
0
R
1
N
0
D
0
C
0
E
0
Q
1
G
0
H
3
I
1
L
6
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 3 L: 1 K: 6 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 2
Chemical Descriptors
15
C87H155N23O17
1795.33
11.21
+6
3.17
-0.167
Evidence Records 4 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
>200 µM
Hemolytic Cytotoxic
50% Hemolysis | >200 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Toxicity study of antimicrobial peptides from wild bee venom and their analogs toward mammalian normal and cancer cells. | Peptides | 2012
Evidence 2 Activity

Activity

IC50
Toxicity
52±7 µM
Cytotoxic
IC50 | 52±7 | µM | target cell: Human umbilical vein endothelial cells HUVEC

Target

Human umbilical vein endothelial cells HUVEC

Source & Reference

NA
DBAASP
Toxicity study of antimicrobial peptides from wild bee venom and their analogs toward mammalian normal and cancer cells. | Peptides | 2012
Evidence 3 Activity

Activity

IC50
Toxicity
40±5 µM
Cytotoxic
IC50 | 40±5 | µM | target cell: Rat epithelial cells IEC-6, CRL-1592

Target

Rat epithelial cells IEC-6, CRL-1592

Source & Reference

NA
DBAASP
Toxicity study of antimicrobial peptides from wild bee venom and their analogs toward mammalian normal and cancer cells. | Peptides | 2012
Evidence 4 Activity

Activity

IC50
Toxicity
200 µM
Hemolytic Cytotoxic
Hemolytic_activity: Rat erythrocytes: IC50>200 µM | Cytotoxicity: HUVEC: IC50=52±7 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Peptides. 2012 Jan 33(1):18-26.