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Peptide record

TPDB24078

Antibacterial Anticancer Antiviral Toxicity standard
30 amino acids
Basic Information
3D PDB MODEL
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TPDB24078
Antibacterial Anticancer Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia AVPpred-BWR dbAMP 3.0 DRAMP DRAVP 2.0 ToxinPred 3.0
standard
No
A 30-aa standard natural multi-activity (Antibacterial, Anticancer, Antiviral, and other sources) peptide sequence curated from Peptipedia, AVPpred-BWR, dbAMP 3.0, and other sources, with an available 3D structural model.
Sequence
NGAICWGPCPTAFRQIGNCGRFRVRCCRIR
Physicochemical Analysis
C144H232N52O35S5
DEHLKMSY
R
3412.05
10.69
6
0
9
+6
0.85
-0.150
55.33
Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour
5750
168.52
9
Residue Composition
number
2
A
6
R
2
N
0
D
5
C
0
E
1
Q
4
G
0
H
3
I
0
L
0
K
0
M
2
F
2
P
0
S
1
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 6 N: 2 D: 0 C: 5 E: 0 Q: 1 G: 4 H: 0 I: 3 L: 0 K: 0 M: 0 F: 2 P: 2 S: 0 T: 1 W: 1 Y: 0 V: 1
Chemical Descriptors
30
C144H232N52O35S5
3412.05
10.69
+6
0.85
-0.150
Evidence Records 4 records
Evidence 1 Activity

Activity

50% Cytotoxicity
Toxicity
>300 µg/mL
Cytotoxic
50% Cytotoxicity | >300 | µg/mL | target cell: Vero E6 cells

Target

Vero E6 cells

Source & Reference

NA
DBAASP
A broad-spectrum virus- and host-targeting peptide against respiratory viruses including influenza virus and SARS-CoV-2. | Nat Commun | 2020
Evidence 2 Activity

Activity

50% Cytotoxicity
Toxicity
>300 µg/mL
Cytotoxic
50% Cytotoxicity | >300 | µg/mL | target cell: Madin-Darby canine kidney cells

Target

Madin-Darby canine kidney cells

Source & Reference

NA
DBAASP
A broad-spectrum virus- and host-targeting peptide against respiratory viruses including influenza virus and SARS-CoV-2. | Nat Commun | 2020
Evidence 3 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.32843628]P9R did not cause the hemolysis of Chicken red blood cells. | Cytotoxicity: [Ref.32843628]the CC50 of P9R was >300 µg/ml for MDCK, VeroE6 and A549 cells.

Target

erythrocytes

Source & Reference

NA
DRAMP
Nat Commun. 2020 Aug 25 11(1):4252.
Evidence 4 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.33750821]no obvious hemolysis was observed when turkey red blood cells were treated at 200 µg/ml. | Cytotoxicity: [Ref.33750821]Vero-E6 cells:the cytotoxicity indicated that TC50 of 8P9R was higher than 200 µg/ml.

Target

erythrocytes

Source & Reference

NA
DRAMP
Nat Commun. 2021 Mar 9 12(1):1517.