TPDB

3D PDB MODEL

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TPDB ID TPDB24076

Activity

Antibacterial

Activity_category_statistics

Anti-infective peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 12-aa standard natural antibacterial peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

NFWKKGKWTIGS

FASTA

>TPDB24076|Antibacterial|length=12
NFWKKGKWTIGS

Formula C70H102N18O16

Absent Amino Acids ARDCEQHLMPYV

Common Amino Acids K

Mass 1451.69

PI 10.84

Basic Residues 3

Acidic Residues 0

Hydrophobic Residues 4

Net Charge +3

Boman Index -1.46

Hydrophobicity -1.000

Aliphatic Index 32.50

Half Life

Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour

Extinction Coefficient Cystines 11000

Absorbance 280nm 757.74

Polar Residues 3

number

0

A

0

R

1

N

0

D

0

C

0

E

0

Q

2

G

0

H

1

I

0

L

3

K

0

M

1

F

0

P

1

S

1

T

2

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 0 K: 3 M: 0 F: 1 P: 0 S: 1 T: 1 W: 2 Y: 0 V: 0

Length

12

Formula

C70H102N18O16

Mass

1451.69

PI

10.84

Net Charge

+3

Boman Index

-1.46

Hydrophobicity

-1.000

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µg/mL

Target

Target Organism Enterobacter cloacae LMG02783

Source & Reference

Database Source NA

Other

Evidence Text

Active against Gram- E. cloacae LMG02783 (MIC 2 ug/ml), E. coli ATCC25922 (MIC 2 ug/m), P. aeruginosa PAO1 (MIC 2 ug/ml), K. pneumoniae LMG20218

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µg/mL

Target

Target Organism Pseudomonas aeruginosa PAO1

Source & Reference

Database Source NA

Other

Evidence Text

Active against Gram- E. cloacae LMG02783 (MIC 2 ug/ml), E. coli ATCC25922 (MIC 2 ug/m), P. aeruginosa PAO1 (MIC 2 ug/ml), K. pneumoniae LMG20218 (MIC 4 ug/ml), P. aeruginosa LMG6395 (MIC 4 ug/ml), A. baumannii

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µg/mL

Target

Target Organism Klebsiella pneumoniae LMG20218

Source & Reference

Database Source NA

Other

Evidence Text

LMG02783 (MIC 2 ug/ml), E. coli ATCC25922 (MIC 2 ug/m), P. aeruginosa PAO1 (MIC 2 ug/ml), K. pneumoniae LMG20218 (MIC 4 ug/ml), P. aeruginosa LMG6395 (MIC 4 ug/ml), A. baumannii ATCC17978 (MIC 4 ug/ml), Gram+ E. faec

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µg/mL

Target

Target Organism Pseudomonas aeruginosa LMG6395

Source & Reference

Database Source NA

Other

Evidence Text

922 (MIC 2 ug/m), P. aeruginosa PAO1 (MIC 2 ug/ml), K. pneumoniae LMG20218 (MIC 4 ug/ml), P. aeruginosa LMG6395 (MIC 4 ug/ml), A. baumannii ATCC17978 (MIC 4 ug/ml), Gram+ E. faecium LMG16003 (VRE) (MIC 2 ug/ml), S.

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µg/mL

Target

Target Organism A. baumannii ATCC17978

Source & Reference

Database Source NA

Other

Evidence Text

(MIC 2 ug/ml), K. pneumoniae LMG20218 (MIC 4 ug/ml), P. aeruginosa LMG6395 (MIC 4 ug/ml), A. baumannii ATCC17978 (MIC 4 ug/ml), Gram+ E. faecium LMG16003 (VRE) (MIC 2 ug/ml), S. aureus ATCC15975 (MRSA) (MIC 4 ug/ml),

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µg/mL

Target

Target Organism B. cereus ATCC14579

Source & Reference

Database Source NA

Other

Evidence Text

Gram+ E. faecium LMG16003 (VRE) (MIC 2 ug/ml), S. aureus ATCC15975 (MRSA) (MIC 4 ug/ml), B. cereus ATCC14579 (MIC 4 ug/ml), E. faecalis LMG16216 (VRE) (MIC 8 ug/ml). Reg 7/2021